Results 51 to 60 of about 161,650 (261)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Influence of Sex, Gender, or Age on Outcomes of Digital Technologies for Treatment and Monitoring of Chronic Obstructive Pulmonary Disease: Protocol for an Overview of Systematic Reviews

JMIR Research Protocols, 2022
BackgroundChronic obstructive pulmonary disease (COPD) is a common chronic disease that can be treated and monitored with various digital technologies.
Katja Matthias, Ivonne Honekamp, Karina Karolina De Santis   +2 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Does moxibustion work? An overview of systematic reviews [PDF]

BMC Research Notes, 2010
Several systematic reviews (SRs) have assessed the effectiveness of moxibustion for a range of conditions, often with contradictory conclusions. Our aim was to provide a critical evaluation and summary of these data.Electronic searches were conducted to locate all SRs of moxibustion for any condition.
Kang Jung Won, Lee Myeong Soo, Ernst Edzard   +2 more
openaire   +3 more sources

Pragmatic methods for reviewing exceptionally large bodies of evidence: systematic mapping review and overview of systematic reviews using lung cancer survival as an exemplar

Systematic Reviews, 2019
Introduction Lung cancer (LC) is the most common cause of cancer death in the world and associated with significant economic burden. We conducted a review of published literature to identify prognostic factors associated with LC survival and determine ...
Ruth Lewis, Maggie Hendry, Nafees Din, Marian A. Stanciu, Sadia Nafees, Annie Hendry, Zhi Hao Teoh, Thomas Lloyd, Rachel Parsonage, Richard D. Neal, Gareth Collier, Dyfed W. Huws   +11 more
doaj   +1 more source

Non-pharmacological strategies for self-directed and interpersonal violence in people with severe mental illness: a rapid overview of systematic reviews

BMJ Open, 2021
Introduction Self-directed and interpersonal violence among people with severe mental illness has become a health priority. Though non-pharmacological interventions have been investigated, to our knowledge, no summary of all systematic reviews on this ...
Maria Concepcion Moreno-Calvete, Francisco Javier Ballesteros-Rodriguez   +1 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Interventions for Neuropathic Pain: An Overview of Systematic Reviews

Anesthesia & Analgesia, 2017
Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Study quality was analyzed using A Measurement Tool to Assess
Došenović, Svjetlana, Jeličić Kadić, Antonia, Miljanović, Maja, Biočić, Marina, Borić, Krste, Ćavar, Marija, Markovina, Nikolina, Vučić, Katarina, Puljak, Livia   +8 more
openaire   +4 more sources

Mesenchymal stem cells for the treatment of articular cartilage defects of the knee: an overview of systematic reviews [PDF]

Anais da Academia Brasileira de Ciências
There is no consensus on the ideal type, dose, expansion, and differentiation of MSCs for treating knee cartilage defects. Our goal was to perform an overview of systematic reviews regarding the use of MSCs for the treatment of articular cartilage ...
EDUARDO B. DE SOUSA, RENATA AKEMI M. MATSUI, LEONARDO C. BOLDRINI, LEANDRA S. BAPTISTA, JOSÉ MAURO GRANJEIRO   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source