Results 61 to 70 of about 161,650 (261)

A propos of systematic reviews, meta-analyses, and systematic review overviews [PDF]

Nutrición Hospitalaria, 2021
Raúl Alberto, Aguilera Eguía, Héctor, Fuentes Barría, Olga, López-Soto   +2 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The state of asthma epidemiology: an overview of systematic reviews and their quality

Clinical and Translational Allergy, 2017
Background Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease.
Jon Genuneit, Annina M. Seibold, Christian J. Apfelbacher, George N. Konstantinou, Jennifer J. Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr, Michael R. Perkin, for the Task Force “Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)” of the EAACI Interest Group on Epidemiology   +9 more
doaj   +1 more source

Consideration of Sex, Gender, or Age on Outcomes of Digital Technologies for Treatment and Monitoring of Chronic Obstructive Pulmonary Disease: Overview of Systematic Reviews

Journal of Medical Internet Research, 2023
BackgroundSeveral systematic reviews have addressed digital technology use for treatment and monitoring of chronic obstructive pulmonary disease (COPD).
Katja Matthias, Ivonne Honekamp, Monique Heinrich, Karina Karolina De Santis   +3 more
doaj   +1 more source

Overview authors rarely defined systematic reviews that are included in their overviews

Journal of Clinical Epidemiology, 2019
To report systematic review definitions that are published in overviews of reviews and to propose a new classification of systematic reviews.In this review of overviews, we searched PubMed for systematic review definitions that were reported in overviews of reviews that were published in the medical literature between November 2017 and May 2018.
Faggion, Clovis Mariano, Diaz, Karla Tatiana   +1 more
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Barriers and facilitators to enrollment in pediatric clinical trials: an overview of systematic reviews

Systematic Reviews
Background Recruiting a sufficient number of patients is often a challenge for conducting clinical trials. Published data reveal that only 10% of eligible patients according to inclusion and exclusion criteria are enrolled in clinical trials ...
Veronika Bencheva, Nina-Kristin Mann, Tanja Rombey, Dawid Pieper, Sven Schmiedl   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Acupuncture for treatment of anxiety, an overview of systematic reviews

Complementary Therapies in Medicine, 2019
To evaluate the methodological quality and summarize evidence of important outcomes of systematic reviews (SRs)/Meta analyses (MAs) of acupuncture for anxiety.We conducted a comprehensive literature search for SRs/MAs in PubMed, EMBASE, Cochrane library, Chinese Biomedical Databases (CBM), Wanfang database and China National Knowledge Infrastructure ...
Meixuan, Li, Xin, Xing, Liang, Yao, Xiuxia, Li, Wenbo, He, Meng, Wang, Huijuan, Li, Xiaoqin, Wang, Yangqin, Xun, Peijing, Yan, Zhenxing, Lu, Biao, Zhou, Xinmin, Yang, Kehu, Yang   +13 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source