Results 101 to 110 of about 259,578 (273)

LncRNA MALAT1 modulates ox-LDL induced EndMT through the Wnt/β-catenin signaling pathway

Lipids in Health and Disease, 2019
Endothelial-to-mesenchymal transition (EndMT) plays significant roles in atherosclerosis, but the regulatory mechanisms involving lncRNAs remain to be elucidated. Here we sort to identify the role of metastasis-associated lung adenocarcinoma transcript 1
Hongrong Li, Qifei Zhao, Liping Chang, Cong Wei, Hongying Bei, Yujie Yin, Meng Chen, Hongtao Wang, Junqing Liang, Yiling Wu   +9 more
semanticscholar   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition [PDF]

Frontiers in Pharmacology, 2017
Aberrant activation of inflammation and excess accumulation of lipids play crucial role in the occurrence and progression of atherosclerosis (AS). Quercetin (QCT) has been tested effectively to cure AS. It is widely distributed in plant foods and has been proved to have potential antioxidative and anticancer activities.
Xue, Feng, Nie, Xiaobo, Shi, Jianping, Liu, Qingxue, Wang, Ziwei, Li, Xiting, Zhou, Jinqiu, Su, Jia, Xue, Mingming, Chen, Wei-Dong, Wang, Yan-Dong   +10 more
openaire   +2 more sources

Astaxanthin suppresses End MT by LOX-1 pathway in ox-LDL-induced HUVECs

European Journal of Inflammation, 2022
Introduction Astaxanthin (ASX) is carotenoid with the highest antioxidant activity in various cell types and reverse atherosclerosis. However, the roles and detailed mechanisms of ASX in atherosclerosis associated endothelial injury remains unclear ...
Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu   +4 more
doaj   +1 more source

Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]

, 2017
Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie, Chen, Renhua, Feng, Weijing, Huang, Hui, Touyz, Rhian M., Wang, Jingfeng, Zhang, Kun, Zhang, Yinyin   +7 more
core   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease

Chronic Diseases and Translational Medicine, 2017
Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD).
Shen Gao, Jing Liu
doaj   +1 more source

Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach. [PDF]

, 2018
BACKGROUND: Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported.
Arós, Fernando, Basora, Josep, Bulló, Mònica, Corella Piquer, Dolores, Covas Planells, María Isabel, Elosua, Roberto, Estruch Riba, Ramon, Fiol Sala, Miguel, Fitó Colomer, Montserrat, Flores Mateo, Gemma, Gómez Gracia, Enrique, Lapetra, José, Martínez-González, Miguel Ángel, 1957-, Rodríguez Blanco, Teresa, Ruiz-Gutiérrez, Valentina, Salas Salvadó, Jordi, Subirana Cachinero, Isaac, Sáez Tormo, Guillermo   +17 more
core   +1 more source

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

TRB3, upregulated by ox‐LDL, mediates human monocyte‐derived macrophage apoptosis [PDF]

The FEBS Journal, 2009
Tribble3 (TRB3), a mammalian homolog of Drosophila tribbles, slows cell‐cycle progression, and its expression is increased in response to various stresses. The aim of this study was to investigate the role of the TRB3 gene in macrophage apoptosis induced by oxidized low‐density lipoprotein (ox‐LDL). We found that, in human monocyte‐derived macrophages,
Yuan-yuan, Shang, Zhi-hao, Wang, Li-ping, Zhang, Ming, Zhong, Yun, Zhang, Jing-ti, Deng, Wei, Zhang   +6 more
openaire   +2 more sources