Results 1 to 10 of about 85,324 (156)

Oxidized low-density lipoprotein cholesterol and plaque vulnerability [PDF]

American Heart Journal Plus
Background: The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formation.
Jun Goto, Daisuke Kinoshita, Yoichiro Otaki, Seisei Ra, Hiroe Ono, Takafumi Mito, Taku Shikama, Shingo Tachibana, Shigehiko Kato, Tetsu Watanabe, Ik-Kyung Jang, Masafumi Watanabe   +11 more
doaj   +2 more sources

Mutation within the transmembrane domain of oxidized low-density lipoprotein receptor 1 influences oxidized low-density lipoprotein-induced signal transduction [PDF]

Innate Immunity
Objective To investigate the important active sites within the NTFs to affect the in vitro interaction of oxidized low-density lipoprotein (ox-LDL) with its receptor, OLR1.
Zhen Ma, Ran Xu, Jing Lu, Xiong Huang, Hao Jia, Zhiwen Ding, Jie Yuan, Yunzeng Zou   +7 more
doaj   +2 more sources

High-frequency ultrasound induced the preparation of oxidized low density lipoprotein [PDF]

Ultrasonics Sonochemistry
Foam cells have been frequently used in studies related to atherosclerosis. Traditional methods for inducing oxidized low-density lipoprotein (oxLDL) involve copper ion (Cu2+) treatment, which has inherent limitations such as prolonged oxidation times ...
Yuanmin Li, Wanyue Yang, Xinyi Zhang, Jingjing Ba, Han Yang, Wen Wang, Ke Zhang, Ze Yang, Hui Liang, Zihan Li, Muthupandian Ashokkumar, Jiguo Zhang, Zhiliang Gao, Yang Yu   +13 more
doaj   +2 more sources

Study on the correlation between oxidized low- density lipoprotein and oxidized high- density lipoprotein with type 2 diabetes complicated by pulmonary tuberculosis [PDF]

BMC Pulmonary Medicine
Objectives This study aims to investigate the correlations between oxidized lipoproteins, specifically oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), and the comorbidities of T2DM and PTB (T2DM + PTB).
Jing Gui, Feng Wang, Chuang-Yue Hong, Yu Fu, Hui Yang, Yu-Mao Cai   +5 more
doaj   +2 more sources

High Levels of Soluble Lectinlike Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background When the lectinlike oxidized low‐density lipoprotein (oxLDL) receptor‐1 (LOX‐1), a scavenger receptor for oxLDL, binds oxLDL, processes leading to endothelial dysfunction and inflammation are promoted.
Hanna Markstad, Andreas Edsfeldt, Ingrid Yao Mattison, Eva Bengtsson, Pratibha Singh, Michele Cavalera, Giuseppe Asciutto, Harry Björkbacka, Gunilla Nordin Fredrikson, Nuno Dias, Petr Volkov, Marju Orho‐Melander, Jan Nilsson, Gunnar Engström, Isabel Gonçalves   +14 more
doaj   +3 more sources

Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process [PDF]

Antioxidants
Atherosclerosis is a complex condition that involves the accumulation of lipids and subsequent plaque formation in the arterial intima. There are various stimuli, cellular receptors, and pathways involved in this process, but oxidative modifications of ...
Marco Munno, Alice Mallia, Arianna Greco, Gloria Modafferi, Cristina Banfi, Sonia Eligini   +5 more
doaj   +2 more sources

Association of circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 with inflammatory markers and urinary albumin excretion in patients with type 2 diabetes

SAGE Open Medicine, 2021
Objectives: The main purpose of the study was to study the association between circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels and various markers, including inflammatory markers such as high-sensitivity C-reactive ...
Kohzo Takebayashi, Tatsuhiko Suzuki, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai, Koshi Hashimoto   +6 more
doaj   +1 more source

Icariin attenuates endothelial-mesenchymal transition via H19/miR-148b-3p/ELF5 in ox-LDL-stimulated HUVECs

Molecular Therapy: Nucleic Acids, 2021
Atherosclerosis is the main cause of cardio-cerebrovascular diseases. Endothelial-mesenchymal transition plays an important role in atherosclerosis. Icariin has a protective effect on atherosclerosis; however, the underlying mechanism remains unclear. In
Shan Liu, Dong-sheng Xu, Min Li, Yang Zhang, Qi Li, Teng-teng Li, Li-qun Ren   +6 more
doaj   +1 more source

Normal and reconstituted high-density lipoprotein protects differentiated monocytes from oxidized low-density lipoprotein-induced apoptosis [PDF]

ARYA Atherosclerosis, 2020
BACKGROUND: The progression of atherosclerosis is an ongoing struggle between cell division and cell death. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a novel receptor for oxidized low-density lipoprotein (ox-LDL), mediates ox-LDL ...
Navkiran Kaur, Savita Kumari, Sujata Ghosh   +2 more
doaj   +1 more source

Involvement of Low‐Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Recently, we and others have reported a causal role for oxidized lipids in the pathogenesis of pulmonary hypertension (PH). However, the role of low‐density lipoprotein receptor (LDL‐R) in PH is not known.
Soban Umar, Gregoire Ruffenach, Shayan Moazeni, Mylene Vaillancourt, Jason Hong, Christine Cunningham, Nancy Cao, Sara Navab, Shervin Sarji, Min Li, Lisa Lee, Greg Fishbein, Abbas Ardehali, Mohamad Navab, Srinivasa T. Reddy, Mansoureh Eghbali   +15 more
doaj   +1 more source