Results 1 to 10 of about 75,484 (307)

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL. [PDF]

PLoS ONE, 2016
Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with type 2 diabetes. Here, we investigated whether the endoplasmic reticulum (ER)
Valérie Plaisance, Saška Brajkovic, Mathie Tenenbaum, Dimitri Favre, Hélène Ezanno, Amélie Bonnefond, Caroline Bonner, Valéry Gmyr, Julie Kerr-Conte, Benoit R Gauthier, Christian Widmann, Gérard Waeber, François Pattou, Philippe Froguel, Amar Abderrahmani   +14 more
doaj   +5 more sources

Preliminary analysis of modified low density lipoproteins in the serum of healthy and obese dogs and cats

Frontiers in Veterinary Science, 2015
Oxidized low-density lipoprotein (LDL) is thought to play an important role in the inflammatory response associated with human obesity. The purpose of this preliminary study was to determine oxidized LDL concentrations in healthy dogs and cats, and to ...
Nobuko eMori, Toshiro eArai
doaj   +1 more source

Involvement of Low‐Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Recently, we and others have reported a causal role for oxidized lipids in the pathogenesis of pulmonary hypertension (PH). However, the role of low‐density lipoprotein receptor (LDL‐R) in PH is not known.
Soban Umar, Gregoire Ruffenach, Shayan Moazeni, Mylene Vaillancourt, Jason Hong, Christine Cunningham, Nancy Cao, Sara Navab, Shervin Sarji, Min Li, Lisa Lee, Greg Fishbein, Abbas Ardehali, Mohamad Navab, Srinivasa T. Reddy, Mansoureh Eghbali   +15 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices

Journal of Lipid Research, 2001
Arterial wall lipid retention is believed to be due primarily to ionic interactions between lipoproteins and proteoglycans. Thus, oxidized low density lipoproteins (LDL), with decreased positive charge relative to native LDL, should have decreased ...
Mary Y. Chang, Susan Potter-Perigo, Thomas N. Wight, Alan Chait   +3 more
doaj   +1 more source

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1

Journal of Lipid Research, 2000
Apolipoprotein A-I (apoA-I) and an apoA-I peptide mimetic removed seeding molecules from human low density lipoprotein (LDL) and rendered the LDL resistant to oxidation by human artery wall cells.
Mohamad Navab, Susan Y. Hama, C. Justin Cooke, G.M. Anantharamaiah, Manjula Chaddha, Linda Jin, Ganesamoorthy Subbanagounder, Kym F. Faull, Srinivasa T. Reddy, Norman E. Miller, Alan M. Fogelman   +10 more
doaj   +1 more source

Oxidised LDL and Serum Paraoxanase Activity in Ischemic Stroke Patients: A Case Control Study [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Oxidative stress by producing lipid peroxidation products like oxidised Low Density Lipoprotein (LDL) acts as independent risk factor in ischemic stroke.
Poornima Bijumon, Geetha Ananthashenoyi, Thomas Iype   +2 more
doaj   +1 more source

Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. [PDF]

, 2011
ObjectiveIn mice, 4F, an apolipoprotein A-I mimetic peptide that restores HDL function, prevents diabetes-induced atherosclerosis. We sought to determine whether HDL function is impaired in type 2 diabetic (T2D) patients and whether 4F treatment improves
Boldrini, Beatrice, Ferrannini, Ele, Fogelman, Alan M, Imaizumi, Satoshi, Morgantini, Cecilia, Natali, Andrea, Navab, Mohamad, Reddy, Srinivasa T   +7 more
core   +1 more source

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3

Journal of Lipid Research, 2000
Treatment of human artery wall cells with apolipoprotein A-I (apoA-I), but not apoA-II, with an apoA-I peptide mimetic, or with high density lipoprotein (HDL), or paraoxonase, rendered the cells unable to oxidize low density lipoprotein (LDL).
Mohamad Navab, Susan Y. Hama, G.M. Anantharamaiah, Kholood Hassan, Greg P. Hough, Andrew D. Watson, Srinivasa T. Reddy, Alex Sevanian, Gregg C. Fonarow, Alan M. Fogelman   +9 more
doaj   +1 more source

Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR [PDF]

, 2013
OxLDL is recognized by macrophage scavenger receptors, including CD36; we have recently found that Platelet-Activating Factor Receptor (PAFR) is also involved.
Ferracini, M., Gidlund, M., Jancar, S., Koga, M.M., Pecenin, M., Rios, F.J.   +5 more
core   +3 more sources