Results 41 to 50 of about 85,473 (301)
Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]
, 2017 A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T. +7 more
core +2 more sources
Journal of Biological Chemistry, 1989 The formation of cholesterol-loaded macrophage foam cells in arterial tissue may occur by the uptake of modified lipoproteins via the scavenger receptor pathway. The macrophage scavenger receptor, also called the acetylated low density lipoprotein (Ac-LDL) receptor, has been reported to recognize Ac-LDL as well as oxidized LDL species such as ...
C P, Sparrow +2 more
openaire +2 more sources
Immunological and functional properties of in vitro oxidized low density lipoprotein.
Journal of Lipid Research, 1995 We studied the effect of in vitro moderate oxidation on low density lipoprotein (LDL) conformation and metabolism. LDL was modified with either copper ions or phospholipase A2 plus lipoxygenase and, in both cases, mild oxidative conditions were used. The
P Harduin +5 more
doaj +1 more source
The oxidative modification of low-density lipoproteins by macrophages [PDF]
Biochemical Journal, 1990 1. Mouse resident peritoneal macrophages in culture modified human 125I-labelled low-density lipoprotein (LDL) to a form that other macrophages took up about 10 times as fast as unmodified LDL. The modified LDL was toxic to macrophages in the absence of serum. 2.
D S, Leake, S M, Rankin
openaire +2 more sources
Paraoxonase 2 protein is spatially expressed in the human placenta and selectively reduced in labour [PDF]
, 2014 Humans parturition involves interaction of hormonal, neurological, mechanical stretch and inflammatory pathways and the placenta plays a crucial role.
A Abdulsid +32 more
core +3 more sources
Oxidative Low Density Lipoprotein and Exercise: A Historical and Meta-Analysis [PDF]
, 2012 PURPOSE: The purpose of this study is to use the meta-analytic approach to determine the impact of exercise on oxidized low density lipoproteins in an adolescent population and the role of oxidized low density lipoprotein in the etiology of ...
Kilgore, Lon +3 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Exercise Attenuated Plasma Oxidized Low-density Lipoprotein and Myeloperoxidase [PDF]
, 2014 Download ...
Koh, Yunsuk, Park, Jin K
core +1 more source
Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]
, 2017 The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria +8 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source