Results 121 to 130 of about 30,682 (325)

3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors

Beilstein Journal of Organic Chemistry, 2015
Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles.
Marion Donnier-Maréchal, David Goyard, Vincent Folliard, Tibor Docsa, Pal Gergely, Jean-Pierre Praly, Sébastien Vidal   +6 more
doaj   +1 more source

Assessment of Spinster homologue 2 (Spns2)‐dependent transport of sphingosine‐1‐phosphate as a therapeutic target

British Journal of Pharmacology, Volume 182, Issue 9, Page 2014-2030, May 2025.
Abstract Background and Purpose Sphingosine‐1‐phosphate (S1P) receptor modulator (SRM) drugs suppress immune system function by disrupting lymphocyte trafficking, but SRMs are broadly immunosuppressive with on‐target liabilities. Another strategy to modulate the immune system is to block S1P transport.
Yugesh Kharel, Tao Huang, Kyle Dunnavant, Daniel Foster, George M. P. R. Souza, Katherine E. Nimchuk, Andrea R. Merchak, Caitlin M. Pavelec, Zuzanna J. Juskiewicz, Simon S. Alexander, Alban Gaultier, Stephen B. G. Abbott, Jung‐Bum Shin, Brant E. Isakson, Wehao Xu, Norbert Leitinger, Webster L. Santos, Kevin R. Lynch   +17 more
wiley   +1 more source

Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles

Anais da Academia Brasileira de Ciências, 2015
An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies.
CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES, YRAIMA CORDEIRO   +10 more
doaj   +1 more source

Silica-supported dichlorophosphate: a recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions [PDF]

, 2008
A series of symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclodehydration of diacylhydrazines by using silica-supported dichlorophosphate as a recoverable cyclodehydrant in solvent-free medium ...
Anguo Zhu, Xiunan Sun, Xue Gong, Xuerong Mao, Zheng Li   +4 more
core   +1 more source

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2 [PDF]

, 2020
A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, 4a–m, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds.
El-Sadek, Mohamed, Elseginy, Samia A., Hamdy, Rania, Jones, Arwyn T., Lashin, El-Said, Westwell, Andrew D., Ziedan, Noha   +6 more
core   +4 more sources

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review

Chemical Biology &Drug Design, Volume 105, Issue 5, May 2025.
Although it is currently only used in veterinary therapy, carprofen proves to be a molecule with a versatile therapeutic potential for human pharmacotherapy. Moreover, the molecule is a target in the drug discovery process for the development of new bioactive compounds.
Carmen Limban, Diana Camelia Nuță, Miron Teodor Caproiu, Denisa Elena Dumitrescu, Șerban Iancu Papacocea, Alexandra Teodora Bordei, Florea Dumitrașcu   +6 more
wiley   +1 more source

The first metal complexes of 3,3'-bi-1,2,4-oxadiazole: A curiously ignored ligand [PDF]

, 2007
The crystal structure of 3,3'-bi-1,2,4-oxadiazole (1) reveals a planar centrosymmetric structure for this molecule in the solid state. It forms a mononuclear complex (3) with palladium(II) chloride, which is shown by X-ray crystallography to contain the ...
Richardson, C., Steel, P.J.
core   +1 more source

The rational design of a Rhodamine fluorescent probe enables the selective detection and bioimaging of salicylic acid in plants under abiotic stress

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1736-1750, May 2025.
Through DFT prediction, a highly selective probe, phoxrodam, was identified and successfully used to detect and bioimage the distribution of SA in the roots of wheat seedlings under salt stress. Summary Abiotic stress severely hinders plant growth and development, resulting in a considerable reduction in crop yields.
Jinjing Wang, Xiaoyan Yang, Lijun Fan, Haojie Ye, Gefei Hao, Peiyi Wang   +5 more
wiley   +1 more source

Core‐Only Calamitic Liquid Crystals: Molecular Design and Optoelectronic Properties

Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.
Side‐chain free or core only rod‐shaped liquid crystals are a rarely studied curiosity. Reported here is a set of molecular design criteria for the preparation of core only conjugated calamitic liquid crystals. Their conjugated polyaromatic structures give them electronic properties required for their use as organic semiconductor and strong ...
Jacob G. Rothera, Jessica Yu, Karla AlNajm, Rita Butrus, Ethan Ahangari‐Bashash, Lara K. Watanabe, Jeremy M. Rawson, Anton Dmitrienko, V. Nicholas Vukotic, S. Holger Eichhorn   +9 more
wiley   +1 more source

An easy synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and arylamidoximes mediated by ethyl chloroformate [PDF]

, 2009
An efficient, clean and easy high-yielding synthesis of 3,5-disubstituted 1,2,4-oxadiazoles starting from mixed anhydrides (generated from carboxylic acids and ethyl chloroformate) and arylamidoximes is ...
José M. Guedes, Natércia M. M. Bezerra, Rajendra M. Srivastava, Ricardo A. W. Neves Filho   +3 more
core   +1 more source