Results 121 to 130 of about 32,424 (300)

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

Journal of Medicinal Chemistry, 2016
Herein, we report the discovery and structure-activity relationships of 5-substituted-2-[(3,5-dinitrobenzyl)sulfanyl]-1,3,4-oxadiazoles and 1,3,4-thiadiazoles as a new class of antituberculosis agents.
Galina Karabanovich, Júlia Zemanová, T. Smutný, R. Székely, M. Šarkan, Ivana Centárová, Anthony Vocat, I. Pavkova, P. Čonka, J. Němeček, J. Stolaříková, M. Vejsová, K. Vávrová, V. Klimešová, A. Hrabálek, P. Pávek, S. Cole, K. Mikušová, Jaroslav Roh   +18 more
semanticscholar   +1 more source

Pharmacophore modelling as useful tool in the lead compounds identification and optimization [PDF]

, 2012
The goal of computer-aided molecular design methods in modern medicinal chemistry is to reduce the overall cost and time associated to the discovery and development of a new drug by identifying the most promising candidates to focus the experimental ...
ALMERICO, Anna Maria, LAURIA, Antonino, MARTORANA, Annamaria, PANTANO, Licia, TUTONE, Marco   +4 more
core  

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

In vivo Anti Inflammation Studies of Novel 1, 2, 5 Oxadiazole Sulfonamide Hybrids [PDF]

, 2021
Hafiz Adnan Ahmad, Muhammad Rahil Aslam, Salman Gul, Tariq Mehmood, Munawar Ali Munawar   +4 more
openalex   +1 more source

Bioactive Azoles with Three Heteroatoms [PDF]

, 2010
This issue is dedicated to scientists belonging to either or both the fields of heterocyclic and medicinal chemistry. Nowadays, pharmaceutical industries are more and more dedicating their research towards different use or applications of the same ...
PACE, A
core  

Fluorescence-based proteasome activity profiling [PDF]

, 2012
With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R., Jong, A., Ovaa, H., Rodenko, B., Schuurman, K.G.   +4 more
core   +1 more source

Stereoselective Synthesis, Synthetic and Pharmacological Application of Monoterpene-Based 1,2,4- and 1,3,4-Oxadiazoles

International Journal of Molecular Sciences, 2017
Stereoselective synthesis of monoterpene-based 1,2,4- and 1,3,4-oxadiazole derivatives was accomplished starting from α,β-unsaturated carboxylic acids, obtained by the oxidation of (−)-2-carene-3-aldehyde and commercially available (−)-myrtenal.
T. Gonda, Péter Bérdi, I. Zupkó, F. Fülöp, Z. Szakonyi   +4 more
semanticscholar   +1 more source

Synthesis of Some Substituted 1,3,4-Oxadiazoles from Hydrazones [PDF]

, 2009
Khalid M. Daoud, Anis Ahmad, Amal N. Ali
openalex   +1 more source

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

E-Journal of Chemistry, 2009
1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activities etc.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
doaj   +1 more source

Synthesis of Novel 3-Acetyl N-methyl-2- Quinolone Derivatives with Expected Antimicrobial Activity

Al-Mustansiriyah Journal of Science, 2018
A series of new 3-Acetyl N-Methyl-2-quinolones oxadiazoles derivatives were synthesized by reaction of 3-acetyl-4-hydroxy-1-methylquinolin-2(1H)-one 3 with ethylbromoacetate to produce compounds 4.
Ghazwan Ali Salman
doaj   +1 more source