Results 81 to 90 of about 85,650 (171)
JCI Insight, 2022 Nephrolithiasis is a common and recurrent disease affecting 9% of the US population. Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two-thirds of all kidney stones.
Onur Cil +4 more
doaj +1 more source
Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi +6 more
wiley +1 more source
Cell Death and DiseaseSeveral forms of regulated necrosis contribute to the pathogenesis of crystal nephropathy, however, the role of pyroptosis, an inflammatory form of cell death involving the formation of gasdermin-D pores in internal and external cell membranes, in this ...
Yoshihiro Kusunoki +8 more
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Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley +1 more source
Pediatric Transplantation, Volume 30, Issue 5, May 2026.ABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Shameer M. Habeeb +8 more
wiley +1 more source
Dysmetabolic nephropathy as a risk factor of pylonephritis in children
Zdorovʹe Rebenka, 2018 Background. Dysmetabolic nephropathies contribute to the development of urinary stone disease in children, the emergence of an infection of the urinary system, secondary pyelonephritis and formation of tubulo-interstitial changes in the kidneys. The main
L.I. Vakulenko
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Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.ABSTRACT Urolithiasis, a condition characterized by the formation of calcium oxalate stones in the urinary tract, remains a significant clinical challenge due to the limited availability of effective preventive therapies. This study investigated the antiurolithic potential of different preparations from Eugenia mattosii, a plant rich in phenolic ...
Bianca Letícia Maciél +8 more
wiley +1 more source
Interleukin-17A mediates cardiorenal injury in oxalate nephropathy [PDF]
AIMS: Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). While CKD is known to give rise to systemic inflammation, its inciting factors remain poorly defined.
Schiattarella, Gabriele G. +22 more
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The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
, 2014 The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
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Redox ReportObjectives To systematically investigate the regulatory mechanisms of ferroptosis in renal tubular epithelial cells under high oxalate stress, focusing on identifying key upstream signaling pathways and their therapeutic potential.Methods We employed HK ...
Junyi Yang +9 more
doaj +1 more source