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Altered glutathione metabolism in oxaliplatin resistant ovarian carcinoma cells
Cancer Letters, 1996Elevation of glutathione (GSH) is commonly observed in cellular resistance to a number of anticancer agents. Most frequently reported change in GSH metabolism that is associated with the elevated GSH levels is increased mRNA expression and activity of gamma-glutamyl cysteine synthetase (gamma GCS), the first enzyme of the GSH biosynthetic pathway.
Z, el-akawi +6 more
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Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
2009Platinum drugs are employed in a wide range of solid tumors, and represent the mainstay of the first-line therapy of ovarian carcinoma. Although cisplatin has shown efficacy in the treatment of different types of tumors including ovarian carcinoma, resistance to treatment is a major limitation.
Laura Gatti, Paola Perego
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TGFB1-mediated autophagy facilitates oxaliplatin resistance in stomach adenocarcinoma
Biochemistry and Cell BiologyIncreasing evidence has indicated that transforming growth factor beta 1 (TGFB1) is engaged in tumorigenesis and progression. Nevertheless, the underlying role and mechanism of TGFB1 in stomach adenocarcinoma (STAD) chemotherapy remains unknown. TGFB1 levels in various types of cancers were first analyzed by the TCGA database.
Qihua Xu +7 more
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Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer
Molecular Therapy, 2021Haiyang Zhang, Xinyi Wang, Kegan Zhu
exaly
Cetuximab sensitivity associated with oxaliplatin resistance in colorectal cancer.
Anticancer research, 2012Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear.The
Lars, Ekblad, Anders, Johnsson
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Oxaliplatin and its derivatives – An overview
Coordination Chemistry Reviews, 2023Paul D O'Dowd +2 more
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The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells
Biomedicine and Pharmacotherapy, 2018Abbas Pirpour Tazehkand +2 more
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