Results 51 to 60 of about 32,827 (233)
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
International Journal of Oncology, 2023 DNA double‑strand break repair is critically involved in oxaliplatin resistance in pancreatic ductal adenocarcinoma (PDAC). Hepatocyte nuclear factor 1 homeobox A (HNF1A) has received increased attention regarding its role in cancer progression. The present study explored the role of HNF1A in oxaliplatin resistance in PDAC.
Xia, Renpeng +8 more
openaire +2 more sources
Cell Death and Disease, 2022 Oxaliplatin resistance is a major challenge in the treatment of colorectal cancer (CRC). Many molecular targeted drugs for refractory CRC have been developed to solve CRC drug resistance, but their effectiveness and roles in the progression of CRC and ...
Xiaohui Shen +10 more
doaj +1 more source
Cells, 2022 Colorectal cancer is the second most common cancer in women, the third in men, and an important cause of cancer-related mortality. Recurrence and the development of chemotherapy resistance are major hindrances for patients’ treatment.
Vanessa Rodríguez-Fanjul +5 more
doaj +1 more source
CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer
British Journal of Cancer, 2022 Abstract Background Colorectal cancer (CRC), the most common cancer type, causes high morbidity and mortality. Patients who develop drug resistance to oxaliplatin-based regimens have short overall survival. Thus, identifying molecules involved in the development of oxaliplatin resistance is critical for designing ...
Chi-Che Hsieh +13 more
openaire +2 more sources
LncRNA CCAT1 enhances chemoresistance in hepatocellular carcinoma by targeting QKI-5
Scientific Reports, 2022 A major reason for treatment failure of cancer is acquisition of drug resistance. The specific mechanisms underlying hepatocellular carcinoma (HCC) chemoresistance need to be fully elucidated.
Chongsheng Xia +4 more
doaj +1 more source
Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells
Oncology Reports, 2011 In spite of an initially promising anti-tumor activity, oxaliplatin-based combinatorial treatments can eventually result in a tumor resistance response. In this study we aimed to understand the role of autophagy in HCC cell resistance to oxaliplatin and to discuss its potential therapeutic implication. We found
Hailei, Du +8 more
openaire +3 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Cell Death Discovery, 2022 The hypoxic microenvironment contributes to the chemoresistance of many malignant tumors including colorectal cancer (CRC). Accumulating studies have indicated that long non-coding RNAs (lncRNAs) play important roles in chemotherapy resistance.
Xingyue Weng +11 more
doaj +1 more source
ANXA3 deletion inhibits the resistance of lung cancer cells to oxaliplatin.
European review for medical and pharmacological sciences, 2020 The purpose of this study was to explore the role of ANXA3 in lung cancer cell resistance to oxaliplatin (OXA).After adding different concentrations of Ox, A549, and A549/Ox cell viability were examined using cell counting kit-8 (CCK-8) assay, and the mRNA and protein expressions of ANXA3 were analyzed by quantitative Real Time-Polymerase Chain ...
Jin, Y.-F., Huang, Y.-T., Chen, P.-F.
openaire +2 more sources
Role of AMPK in Regulation of Oxaliplatin-Resistant Human Colorectal Cancer
Biomedicines, 2022 Oxaliplatin is a platinum analog that can interfere with DNA replication and transcription. Continuous exposure to oxaliplatin results in chemoresistance; however, this mechanism is not well known. In this study, oxaliplatin-resistant (OR) colorectal cancer (CRC) cells of HCT116, HT29, SW480 and SW620 were established by gradually increasing the drug ...
Sun Young Park +3 more
openaire +3 more sources