Isolated Kidney Transplant in Primary Hyperoxaluria-1 Enabled by Small Interfering RNA (siRNA) Therapy. Is It Time for Change? Case Report and Review of the Literature. [PDF]
Pediatr TransplantABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Habeeb SM +8 more
europepmc +2 more sources
Surgical Management of Pediatric Primary Hyperoxaluria Type 1: An Eight-Patient Case Series in the Pre-siRNA Era. [PDF]
Pediatr TransplantABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder that leads to systemic oxalosis and end‐stage renal disease (ESRD). Before the advent of siRNA therapy, liver transplantation, often combined with kidney transplantation, was the only definitive treatment.
Finer G +5 more
europepmc +2 more sources
Pathology of Free-Living Loggerhead Turtle (Caretta caretta) Embryos on the Island of Linosa (Italy) [PDF]
Veterinary SciencesOn the beach of Linosa Island (Italy), 43 loggerhead sea turtle (Caretta caretta) unhatched eggs were recovered from nests, formalin-fixed and necropsied.
Frine Eleonora Scaglione +11 more
doaj +2 more sources
Catastrophic retinal vascular occlusion and vision loss due to crystal deposition in end-stage kidney disease treated with peritoneal dialysis [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To report two cases of catastrophic retinal vascular occlusion and crystalline retinopathy due to presumed oxalosis and hyperphosphatemia.
Delu Song +7 more
doaj +2 more sources
Primary hyperoxaluria type I diagnosed after a kidney transplant presenting with subcutaneous calcification: a case report of sodium thiosulfate treatment [PDF]
Frontiers in PharmacologyPrimary hyperoxaluria (PH) is a rare autosomal recessive disorder that results from the overproduction of endogenous oxalate. The diagnosis of PH is often delayed or missed owing to its rarity, variable clinical expression and other diagnostic challenges.
Min Wu +7 more
doaj +2 more sources
Bone health in children with primary hyperoxaluria type 1 following liver and kidney transplantation [PDF]
Frontiers in PediatricsBackgroundPrimary hyperoxaluria type 1 is characterized by hepatic oxalate overproduction, leading to nephrocalcinosis, kidney stones, kidney failure and systemic oxalosis, including oxalate osteopathy.
Rainer Büscher +2 more
doaj +2 more sources
Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients [PDF]
Renal FailureObjectives Calcium oxalate (CaOx) crystal deposition in acute kidney injury (AKI) patients is under recognized but impacts renal outcomes. This study investigates its determinants and effects.Methods We studied 814 AKI patients with native kidney ...
Weiwei Yang +5 more
doaj +2 more sources
BMC Nephrology, 2020 Background Xylitol is an approved food additive that is widely used as a sweetener in many manufactured products. It is also used in pharmaceuticals. Secondary oxalosis resulting from high dietary oxalate has been reported.
Shinobu Takayasu +10 more
doaj +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2014 Renal oxalate deposition can be seen with primary hyperoxaluria, malabsorptive states, ethylene glycol toxicity and, rarely, with excessive vitamin C ingestion.
S Yaich +8 more
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