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Preliminary Investigations of Some Derivatives of Oxamniquine
Journal of Chemotherapy, 1995Oxamniquine is a potent schistosomicide used clinically in the treatment of infections due to Schistosoma mansoni. Although relatively well tolerated, some central nervous system (CNS) effects characterised by convulsions have been reported in a small proportion of the population receiving this drug.
C W, Karekezi +3 more
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Pharmacokinetics of oxamniquine in rabbit and rat
European Journal of Drug Metabolism and Pharmacokinetics, 1996The pharmacokinetics of the schistosomicidal agent oxamniquine (6-hydroxmethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetra hydroquinoline) were studied in 8 (4 male, 4 female) New Zealand White rabbits and 5 female Wistar rats, following intravenous administration (15 mg/kg).
Kokwaro, GO, Indalo, Anne A, Taylor, G
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Determination of oxamniquine in capsules by HPLC
Journal of Pharmaceutical and Biomedical Analysis, 2001A sensitive, accurate, reliable and easy method was developed for the quantification of oxamniquine in capsules using high-performance liquid chromatography (HPLC) with UV detection. This technique provided conditions for the separation of the active ingredient from the dosage form by extraction in methanol.
Pierri, E. G. +2 more
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Binding of oxamniquine to the DNA of schistosomes
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989Hycanthone-sensitive and hycanthone-resistant schistosomes (which are also sensitive and resistant to oxamniquine) were exposed in vitro to tritium-labelled oxamniquine. The initial uptake of the drug into the schistosomes was essentially the same for the 2 strains.
L, Pica-Mattoccia, D, Cioli, S, Archer
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Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine
Bioorganic & Medicinal Chemistry, 2017Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in poverty conditions, contribute to the maintenance of social inequality, being a strong barrier to a country development. Schistosomiasis, a NTD, is a tropical and subtropical disease caused by the trematode Schistosoma mansoni (Africa, Middle East, Caribbean, Brazil,
VinÃcius Barros Ribeiro da Silva +4 more
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The metabolism of oxamniquine in the gut wall
Xenobiotica, 19801. The extent of metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, in the gut of the dog has been studied using an intestinal preparation which allows collection of the outflow from the portal vein. 2.
B, Kaye, D W, Roberts
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Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan
Journal of Antimicrobial Chemotherapy, 1987Oxamniquine pharmacokinetics were determined in five normal Sudanese subjects and nine Sudanese patients with advanced hepatosplenic schistosomiasis, given 1 g as a single oral dose. There were no significant differences in oxamniquine mean area under the plasma concentration time curve (AUC), plasma half life (T1/2), or time to reach peak ...
T K, Daneshmend, M A, Homeida
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A review of clinical experience with oxamniquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. The drug has been used
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
H, Stokvis +4 more
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H, Stokvis +4 more
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Seizures and Electroencephalograph Changes Associated with Oxamniquine Therapy
The American Journal of Tropical Medicine and Hygiene, 1978A Tanzanian man with a known seizure disorder was admitted to hospital for treatment of schistosomiasis mansoni. He suffered a grand mal seizure soon after the second dose of oxamniquine. This is the first recorded seizured associated with use of this drug.
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