Results 121 to 130 of about 709 (171)
Some of the next articles are maybe not open access.
Seizures Associated with Oxamniquine Therapy
The American Journal of Tropical Medicine and Hygiene, 1986Three patients who were treated for schistosomiasis mansoni with oxamniquine suffered generalized seizures. We suggest that this side effect may be more common than previously reported. Specific ethnic groups may be particularly at risk.
H, Stokvis +4 more
openaire +2 more sources
The metabolism of oxamniquine—a new schistosomicide
Annals of Tropical Medicine & Parasitology, 1976The metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, has been studied in the mouse, rat, hamster, rabbit, rhesus monkey, dog and man. Urinary excretion is a major route of elimination in man. The compound is converted to two metabolites, the major one arising from oxidation of the 6-hydroxymethyl ...
B, Kaye, N M, Woolhouse
openaire +2 more sources
Tolerance of Kenyan Schistosoma mansoni to oxamniquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987Although 30 mg/kg oxamniquine produced high levels (85.5 to 99.5%) of egg reduction in Kenyan children infected with Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children confirmed this lower cure rate (36% v. 83%).
COLES, GC +4 more
openaire +3 more sources
Studies on some derivatives of oxamniquine
Journal of Medicinal Chemistry, 1988On the basis of the remarkable biological similarities between hycanthone and oxamniquine and as a sequel to our finding that some esters of hycanthone are active against hycanthone-resistant schistosomes, we prepared oxamniquine acetate, oxamniquine N-methylcarbamate, and four substituted phenylsulfonohydrazones of oxamniquine aldehyde.
W, el-Hamouly +4 more
openaire +2 more sources
Chemotherapy of schistosomal colonic polyposis with oxamniquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1978Schistosomal polyposis of the colon is a common complication of schistosomiasis. In severe infections it may be associated with considerable morbidity. Surgery is associated with high morbidity and mortality. Niridazole therapy is of limited therapeutic value because of its hepatotoxicity but oxaminiquine has been found to be effective and safe ...
H H, Abaza +3 more
openaire +2 more sources
Treatment of Complicated Schistosomiasis Mansoni with Oxamniquine
The American Journal of Tropical Medicine and Hygiene, 1978Twenty male patients (mean age 23 years) with Schistosoma mansoni infections (mean egg count 429 +/- 311/g feces) were each treated with oxamniquine orally in a single daily dose of 20 mg/kg for 3 consecutive days. Seventeen patients had hepatosplenomegaly, two of these had ascites. Three patients had diffuse colonic polyposis, one of these had ascites.
S, Bassily +3 more
openaire +2 more sources
Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan
Journal of Antimicrobial Chemotherapy, 1987Oxamniquine pharmacokinetics were determined in five normal Sudanese subjects and nine Sudanese patients with advanced hepatosplenic schistosomiasis, given 1 g as a single oral dose. There were no significant differences in oxamniquine mean area under the plasma concentration time curve (AUC), plasma half life (T1/2), or time to reach peak ...
T K, Daneshmend, M A, Homeida
openaire +2 more sources
Preliminary Investigations of Some Derivatives of Oxamniquine
Journal of Chemotherapy, 1995Oxamniquine is a potent schistosomicide used clinically in the treatment of infections due to Schistosoma mansoni. Although relatively well tolerated, some central nervous system (CNS) effects characterised by convulsions have been reported in a small proportion of the population receiving this drug.
C W, Karekezi +3 more
openaire +2 more sources
A review of clinical experience with oxamniquine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. The drug has been used
openaire +2 more sources
The toxicology of the schistosomicidal agent oxamniquine
Drug Development Research, 1984AbstractOxamniquine displayed low acute toxicity in mice, hamsters, and rabbits. In rats, however, oxamniquine was much more toxic, the female being 8–10 times more sensitive than the male; single doses elicited an idiosyncratic sex‐linked hepatic necrosis and bile duct proliferation.
M. Chvédoff +7 more
openaire +1 more source