Results 1 to 10 of about 208 (129)

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways. [PDF]

Angew Chem Int Ed Engl
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Kim YE, Kim J, Lee J, Hong S.
europepmc   +3 more sources

Metal-Free, Chemoselective Reduction of Aromatic Nitro Compounds in Water at Room Temperature. [PDF]

ChemistryOpen
A metal‐free, rapid, and chemoselective nitro reduction of aromatic compounds is developed using tetrahydroxydiboron as reducing agent and 4,4′‐bipyridine as organocatalyst. This green method provides an efficient entry to aromatic amines with high functional group tolerance in excellent yields under mild conditions using water as solvent. A metal‐free,
Batzaki M, Heugebaert TSA, Stevens CV.
europepmc   +2 more sources

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ZC3H13 promotes HNSCC progression and anti‐PD‐1 resistance by enhancing IGF2BP1‐mediated stabilization of CCND1 mRNA in an m6A‐dependent manner. Targeting ZC3H13 suppresses oral tumorigenesis and improves response to PD‐1 blockade. Abstract Background Resistance to immune checkpoint blockade substantially limits its clinical efficacy in head and neck ...
Wenqing Chen, Yun Li, Shuang Chen, Caihua Zhang, Zhi Liu, Kai Sun, Yingyi Li, Chunlong Yang, Wenbin Lei, Kang Li   +9 more
wiley   +1 more source

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 822-836, August 2026.
ABSTRACT Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease pathogenesis remains limited.
Nikhil Mongia, Ali Ibrahim Mohammed, Michael McCullough, Rita Paolini, James A. Rickard, Massimo Mascolo, Silvia Varricchio, Lorraine A. O'Reilly, John Silke, Nicola Cirillo, Antonio Celentano   +10 more
wiley   +1 more source

Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 755-773, August 2026.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, associated with substantial morbidity and mortality worldwide. Oral epithelial dysplasia (OED) can precede OSCC, offering a critical window for preventive and therapeutic intervention.
Zilefac Brian Ngokwe, Satutya Wicaksono, Michael McCullough, Antonio Celentano, Tami Yap   +4 more
wiley   +1 more source

Evaluation of Novel Cloxyquin Analogs for K2P18.1 Channel Modulation

Archiv der Pharmazie, Volume 359, Issue 7, July 2026.
5‐Chloro‐/5‐bromoquinolines reveal how subtle changes at the 8‐position of the quinoline scaffold tune activity at hK2P18.1 channels. Among 14 synthesized derivatives, benzaldimine 3d emerged as a new lead for activator optimization potentiating hK2P18.1 activity by around 60% at 100 µM.
Jasmin Sörgel, Marcel Kloth, Henning Klaasen, Sven G. Meuth, Thomas Budde, Bart Jan Ravoo, Julian A. Schreiber   +6 more
wiley   +1 more source

Curcumin Attenuates Aroclor 1254‐Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
In HepG2 cells, Aroclor 1254 induced oxidative stress, DNA damage, apoptosis, and mutagenicity; co‐treatment with curcumin restored antioxidant defenses (GSH/thiols; SOD, CAT, GPx, GR, TrxR), reduced ROS and comet/8‐OHdG readouts, and attenuated caspase activation, demonstrating curcumin's hepatoprotective and genoprotective modulation of PCB toxicity.
Pınar Erkekoğlu, Selinay Başak Erdemli Köse, Hülya Tezel Yalçın, Deniz Arca Çakır   +3 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source