Results 1 to 10 of about 3,474 (171)

Food-Associated Lactobacillus plantarum and Yeasts Inhibit the Genotoxic Effect of 4-Nitroquinoline-1-Oxide [PDF]

Frontiers in Microbiology, 2017
Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and ...
Roberta Prete, Rosanna Tofalo, Ermanno Federici, Aurora Ciarrocchi, Giovanni Cenci, Aldo Corsetti   +5 more
doaj   +4 more sources

Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism [PDF]

Frontiers in Microbiology, 2018
Microbiota has been widely considered to play a critical role in human carcinogenesis. Human papilloma virus, hepatitis B and C virus, and Helicobacter pylori are implicated in the pathogenesis of cancer of uterine cervix, liver, and stomach ...
Jia-shun Wu, Min Zheng, Mei Zhang, Xin Pang, Li Li, Sha-sha Wang, Xiao Yang, Jing-biao Wu, Ya-jie Tang, Ya-ling Tang, Xin-hua Liang   +10 more
doaj   +4 more sources

4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment [PDF]

Frontiers in Oncology
Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis.
Kjersti Sellæg, Ruth Schwienbacher, Ruth Schwienbacher, Mathias Kranz, Anna Engan Aamodt, Anna M. Wirsing, Gerd Berge, Elin Hadler-Olsen, Elin Hadler-Olsen, Synnøve Norvoll Magnussen   +9 more
doaj   +4 more sources

Fat and exposure to 4-nitroquinoline-1-oxide causes histologic and inflammatory changes in murine livers. [PDF]

PLoS ONE, 2022
Risk factors for liver cancer include tobacco use, alcohol consumption, obesity, and male sex. Administration of 4-nitroquinonline-1-oxide (4NQO) in drinking water mimics the effects of tobacco and leads to oral carcinoma in mice. This study compared the
Lenore D Pitstick, Joanna Goral, Ryan A Schmelter, Christine M Fuja, Mae J Ciancio, Matthew Pytynia, Alice Meyer, Jacalyn M Green   +7 more
doaj   +3 more sources

4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development [PDF]

Frontiers in Immunology, 2023
4-Nitroquinoline N-oxide (4-NQO) and its derivatives react with genomic DNA to form stable quinolone monoadducts, which are highly mutagenic and genotoxic.
Satya Ranjan Sahu, Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Premlata Kumari, Ipsita Subhadarsini, Ipsita Subhadarsini, Narottam Acharya   +11 more
doaj   +2 more sources

Areca nut extract increased stromal tumor-infiltrating lymphocytes in 4-nitroquinoline-1-oxide-tumor-induced Sprague-Dawley rats [version 4; peer review: 1 approved, 2 approved with reservations] [PDF]

F1000Research, 2022
Background Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers with a high mortality rate. The biodiversity source in Indonesia makes areca nut a potential antioxidant in treating disease.
Dina Keumala Sari, Cut Fera Novita, Poppy Andriany, Liza Meutia Sari   +3 more
doaj   +2 more sources

Correction to: Alleviation of 4-nitroquinoline 1-oxide induced oxidative stress by Oroxylum indicum (L.) leaf extract in albino Wistar rats [PDF]

BMC Complementary Medicine and Therapies, 2022
An amendment to this paper has been published and can be accessed via the original article.
Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agrawal, Rajasekaran Chandrasekaran   +6 more
doaj   +2 more sources

Effect of exposure to the carcinogen 50 ppm 4-nitroquinoline 1-oxide on alveolar bone loss [PDF]

Journal of Indian Society of Periodontology
Background: The objective of this study was to analyze the effect of exposure to the carcinogen 4-nitroquinoline 1-oxide (4NQO), with or without experimental periodontitis (EP), on alveolar bone loss (ABL) in rats. Materials and Methods: Male Wistar rats
Marcelo Ekman Ribas, Tobias Rauber Spuldaro, Harry Juan Rivera Oballe, Juliano Cavagni, Eduardo José Gaio, Marcelo Lazzaron Lamers, Francisco Wilker Mustafa Gomes Muniz, Cassiano Kuchenbecker Rösing   +7 more
doaj   +2 more sources

Use of 4-Nitroquinoline 1-Oxide (4NQO) in Dysplastic and Malignant Induction: In Vitro and In Vivo Studies [PDF]

Biomedicines
Objectives: Tobacco has been associated with the development of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). This study aimed to evaluate the in vitro and in vivo changes caused by carcinogen 4-nitroquinoline 1-oxide (4NQO), simulating ...
Daniela Oliveira Meneses, Brunna da Silva Nobrega Souza, Mateus José Dutra, Isabella Souza Malta, Bruna Oliveira Silva, Isis Moraes Cançado, Nathan Stevan Cezar Conceição, Maria Leticia de Almeida Lança, Luana Marotta Reis de Vasconcellos, Estela Kaminagakura   +9 more
doaj   +2 more sources

Therapeutic Efficacy of Orally Delivered Doxorubicin Nanoparticles in Rat Tongue Cancer Induced by 4-Nitroquinoline 1-Oxide [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell carcinoma makes up about 94% of oral malignancies.
Monir Moradzadeh Khiavi, Ahamd Rostami, Hamed Hamishekar, Mehran Mesgari Abassi, Amirala Aghbali, Roya Salehi, Bita Abdollahi, Soheila Fotoohi, Mahmud Sina   +8 more
doaj   +2 more sources