Results 31 to 40 of about 3,474 (171)

Spatial transcriptomic analysis of 4NQO-induced tongue cancer revealed cellular lineage diversity and evolutionary trajectory

Frontiers in Oncology
IntroductionSpatial transcriptomic analysis has proposed valuable insights into the behavior of tongue cancer. However, the specific cell types involved in chemically-induced carcinogenesis and the process of tumor development remain elusive.MethodsWe ...
Feng Liu, Feng Liu, Xiaojun Wu, Shaoqing Yu, Deqiang Cheng, Jun Pan, Xiaodong Wang, Guanzhen Yu, Guanzhen Yu, Chaofu Li   +9 more
doaj   +1 more source

Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]

PLoS ONE, 2017
The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima, Camila Regina do Vale, Jefferson Hollanda Véras, Aline Bernardes, Caridad Noda Pérez, Lee Chen-Chen   +5 more
doaj   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

The influence of sleep deprivation on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Dental Research Journal, 2013
Background: The aim of this study was to evaluate whether paradoxical sleep deprivation could affects the mechanisms and pathways essentials for cancer cells in tongue cancer induced by 4-nitroquinole 1-oxide in Wistar rats.
Juliana Noguti, Tathiana Aparecida Alvarenga, Mônica Levy Andersen, Sergio Tufik, Celina Tijuko Fujiyama Oshima, Daniel Araki Ribeiro   +5 more
doaj   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. [PDF]

PLoS Genetics, 2008
Complex traits typically involve the contribution of multiple gene variants. In this study, we took advantage of a high-density genotyping analysis of the BY (S288c) and RM strains of Saccharomyces cerevisiae and of 123 derived spore progeny to identify ...
Ann Demogines, Erin Smith, Leonid Kruglyak, Eric Alani   +3 more
doaj   +1 more source

TNFα Signaling Is Increased in Progressing Oral Potentially Malignant Disorders and Regulates Malignant Transformation in an Oral Carcinogenesis Model

Frontiers in Oncology, 2021
Oral carcinogenesis represents a multi-stage process which encompasses several genetic and molecular changes that promote the progression of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinomas (OSCCs).
Jeffrey W. Chadwick, Jeffrey W. Chadwick, Rachel Macdonald, Aiman A. Ali, Michael Glogauer, Michael Glogauer, Marco A. Magalhaes, Marco A. Magalhaes   +7 more
doaj   +1 more source

Effect of aluminium chloride on metabolism of 4-nitroquinoline 1-oxide.

Gan, 1979
Aluminium chloride was subcutaneously administered to mice and its effect on the activities of 4-nitroquinoline 1-oxide (4-NQO) reductase and 4-hydroxyaminoquinoline 1-oxide (4-HAQO) reductase, and the organ distribution of carcinogen(s) in mouse lung and liver were examined.
YAMANE, Yasuhiro, OHTAWA, Masakatsu
openaire   +2 more sources

ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ZC3H13 promotes HNSCC progression and anti‐PD‐1 resistance by enhancing IGF2BP1‐mediated stabilization of CCND1 mRNA in an m6A‐dependent manner. Targeting ZC3H13 suppresses oral tumorigenesis and improves response to PD‐1 blockade. Abstract Background Resistance to immune checkpoint blockade substantially limits its clinical efficacy in head and neck ...
Wenqing Chen, Yun Li, Shuang Chen, Caihua Zhang, Zhi Liu, Kai Sun, Yingyi Li, Chunlong Yang, Wenbin Lei, Kang Li   +9 more
wiley   +1 more source

5-Methoxytryptophan Sensitizing Head and Neck Squamous Carcinoma Cell to Cisplatitn Through Inhibiting Signal Transducer and Activator of Transcription 3 (STAT3)

Frontiers in Oncology, 2022
Head and neck squamous cell carcinoma (HNSCC) is a common cancer of the oral cavity. Cisplatin (CDDP) is the ideal chemo-radiotherapy used for several tumor types, but resistance to the drug has become a major obstacle in treating patients with HNSCC.
Yu-Chieh Su, Yu-Chieh Su, Chih-Chun Wang, Chih-Chun Wang, Jui-Hsi Weng, Shyh-An Yeh, Shyh-An Yeh, Po-Jen Chen, Tzer-Zen Hwang, Tzer-Zen Hwang, Huang-Chi Chen, Huang-Chi Chen   +11 more
doaj   +1 more source