Results 41 to 50 of about 3,474 (171)

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 822-836, August 2026.
ABSTRACT Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease pathogenesis remains limited.
Nikhil Mongia, Ali Ibrahim Mohammed, Michael McCullough, Rita Paolini, James A. Rickard, Massimo Mascolo, Silvia Varricchio, Lorraine A. O'Reilly, John Silke, Nicola Cirillo, Antonio Celentano   +10 more
wiley   +1 more source

Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 755-773, August 2026.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, associated with substantial morbidity and mortality worldwide. Oral epithelial dysplasia (OED) can precede OSCC, offering a critical window for preventive and therapeutic intervention.
Zilefac Brian Ngokwe, Satutya Wicaksono, Michael McCullough, Antonio Celentano, Tami Yap   +4 more
wiley   +1 more source

Synthesis and Reaction of 3-Fluoro-4-nitroquinoline 1-Oxide

Chemical and Pharmaceutical Bulletin, 1968
3-Fluoroquinoline 1-oxide, which was prepared through the Schiemann reaction of 3-aminoquinoline, followed by N-oxygenation, was nitrated to 3-fluoro-4-nitroquinoline 1-oxide. The fluorine atom of this compound was replaced with nucleophiles such as OR- or NR2-containing compounds in neutral or alkaline media to afford 3-substituted 4-nitroquinoline 1 ...
ARAKI, MISAKO, SANEYOSHI, MINEO, HARADA, HARUE, KAWAZOE, YUTAKA   +3 more
openaire   +3 more sources

Curcumin Attenuates Aroclor 1254‐Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
In HepG2 cells, Aroclor 1254 induced oxidative stress, DNA damage, apoptosis, and mutagenicity; co‐treatment with curcumin restored antioxidant defenses (GSH/thiols; SOD, CAT, GPx, GR, TrxR), reduced ROS and comet/8‐OHdG readouts, and attenuated caspase activation, demonstrating curcumin's hepatoprotective and genoprotective modulation of PCB toxicity.
Pınar Erkekoğlu, Selinay Başak Erdemli Köse, Hülya Tezel Yalçın, Deniz Arca Çakır   +3 more
wiley   +1 more source

TGFβ+ small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

Journal of Extracellular Vesicles, 2022
Transforming growth factor β (TGFβ) is a major component of tumor‐derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ+ TEX to promote tumor growth and pro‐tumor activities in the tumor microenvironment (TME) are ...
Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Monika Pietrowska, Piotr Widłak, Cynthia S. Hinck, Alicja Głuszko, Mirosław J. Szczepański, Teresa Kärmer, Isabella Kallinger, Daniela Schulz, Richard J. Bauer, Gerrit Spanier, Steffen Spoerl, Johannes K. Meier, Tobias Ettl, Beatrice M. Razzo, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside   +19 more
doaj   +1 more source

Responses of entomopathogenic fungi to the mutagen 4-nitroquinoline 1-oxide

Fungal Biology, 2018
Survival of entomopathogenic fungi under solar ultraviolet (UV) radiation is paramount to the success of biological control of insect pests and disease vectors. The mutagenic compound 4-nitroquinoline 1-oxide (4-NQO) is often used to mimic the biological effects of UV radiation on organisms.
Claudinéia A.S. Araújo, Luciana P. Dias, Paulo C. Ferreira, Josane Mittmann, Breno Pupin, Guilherme.T.P. Brancini, Gilberto Ú.L. Braga, Drauzio E.N. Rangel   +7 more
openaire   +3 more sources

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Scientific Report on consumer health‐based guidance values for trifluoroacetic acid

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to provide a scientific report according to Article 31 of Regulation (EC) No 178/2002, in conjunction with Regulation (EC) No 1107/2009, to revise consumer health‐based guidance values, i.e. acceptable daily intake (ADI) and acute reference dose (ARfD), for trifluoroacetic acid (TFA). EFSA launched a targeted
EFSA (European Food Safety Authority), Adeline Cavelier, Tamara Coja, Andrea Gall, Antonio Hernández‐Jerez, Christiane Vleminckx, Elodie Bergsma, Marco Binaglia, Federica Crivellente, Mathilde Colas, Anna Lanzoni, Jochem Louisse, Rafaela Rodrigues De Jesus, Annetta Grillo, Iris Mangas, Juan Manuel Parra Morte   +15 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Conserved Active Site Loop Residues of E. coli DinB and Human DNA Polymerase Kappa Govern Activity

Environmental and Molecular Mutagenesis, Volume 67, Issue 5-7, June‐August 2026.
ABSTRACT DNA damage is ubiquitous and can arise from numerous sources. To mitigate the potential effects of DNA damage, cells possess varied DNA repair and damage tolerance mechanisms. Conserved throughout evolution, specialized DNA damage‐bypass DNA polymerases from the Y family provide DNA damage tolerance. E.
Nicole M. Antczak, Paul Ippoliti, Jiyoun Ahn, Lakindu Pathira Kankanamge, Tamara Dudko, Khadijah Balfour‐Jeffrey, Bix Pancoe, Zoe MacDiarmid, Chuc May Pham, David Williams, Alexandra Mora, Jason M. Walsh, Penny J. Beuning   +12 more
wiley   +1 more source