Results 61 to 70 of about 3,474 (171)

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, Volume 117, Issue 4, Page 1010-1025, April 2026.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in Experimental Tongue Squamous Cell Carcinoma Induced by 4-Nitroquinoline-1-Oxide—A Pilot Study

Open Veterinary Journal
Background: Oral squamous cell carcinoma of the tongue is the most common type of head and neck malignancy and is associated with poor survival.
Akeem Moradehun Bamiro, Zul Izhar Mohd Ismail, Sharifah Emilia Tuan Sharif, Tengku Ahmad Damitri Al-Astani Tengku Din, Nasibah Mohamad, Luqman Afiq Mohamad Ishak, Samir Acherar, Philippe Arnoux, Celine Frochot, Norhafiza Mat Lazim   +9 more
doaj   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, Volume 46, Issue 3, Page 950-960, March 2026.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Excision in vitro of the DNA bound carcinogen, 4-nitroquinoline 1-oxide

Nucleic Acids Research, 1976
It has been shown that 4-hydroxyaminoquinoline 1-oxide, the proximate form of the carcinogen 4-nitroquinoline 1-oxide, binds covalently to the purine bases of DNA. Here we report that carcinogen-bound nucleotides can be excised from DNA by a 5' leads to 3' exonuclease associated with DNA polymerase I of E. coli in the forms of either mononucleotides or
S, Yoshida, M, Tada, M, Tada
openaire   +3 more sources

Construction of a nrdA::luxCDABE Fusion and Its Use in Escherichia coli as a DNA Damage Biosensor

Sensors, 2008
The promoter of nrdA gene which is related with DNA synthesis was used to construct a DNA damage sensitive biosensor. A recombinant bioluminescent E.
Man Bock Gu, Byoung Chan Kim, Joo- Myung Ahn, Ee Taek Hwang   +3 more
doaj  

Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis

Biochemistry and Biophysics Reports
Tobacco smoking and alcohol consumption are significant risk factors for esophageal squamous cell carcinoma (ESCC), with their Collaborative interaction amplifying carcinogenic risks.
Jianfeng Yuan, Jianxin Guo, Yu Wang, Tiantian Xing, Shuang Hou, Chenchen Zhang, Ming Huang, Pengfei Zheng, Ruifeng Li, Zhongbing Wu, Jing Li   +10 more
doaj   +1 more source

Molecular Basis of 4‐Nitroquinoline 1‐Oxide Carcinogenesis [PDF]

Japanese Journal of Cancer Research, 1989
Bailleul, Bernard, Daubersies, Pierre, Galiègue‐Zouitina, Sylvie, Loucheux‐Lefebvre, Marie‐Henriette   +3 more
openaire   +2 more sources

A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia. [PDF]

Vet Pathol, 2023
Aziz Z, Washington MK, Jacobse J, Choksi Y.   +3 more
europepmc   +1 more source