Results 21 to 30 of about 3,474 (171)

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma

Molecular Therapy: Oncolytics, 2021
Prognosis for advanced oral carcinoma remains poor. Oncolytic virotherapy uses replication-competent viruses to infect and kill only the tumor cells. However, it has been difficult to investigate the oncolytic activity of viruses against oral carcinomas ...
Gaku Takano, Shinichi Esaki, Fumi Goshima, Atsushi Enomoto, Yoshimi Hatano, Haruka Ozaki, Takahiro Watanabe, Yoshitaka Sato, Daisuke Kawakita, Shingo Murakami, Takayuki Murata, Yukihiro Nishiyama, Shinichi Iwasaki, Hiroshi Kimura   +13 more
doaj   +1 more source

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

Frontiers in Oncology, 2021
An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa.
Natarajan Bhaskaran, Sangeetha Jayaraman, Cheriese Quigley, Prerna Mamileti, Mahmoud Ghannoum, Mahmoud Ghannoum, Aaron Weinberg, Aaron Weinberg, Jason Thuener, Quintin Pan, Quintin Pan, Pushpa Pandiyan, Pushpa Pandiyan, Pushpa Pandiyan   +13 more
doaj   +1 more source

Novel Genes Involved in Resistance to Both Ultraviolet Radiation and Perchlorate From the Metagenomes of Hypersaline Environments

Frontiers in Microbiology, 2020
Microorganisms that thrive in hypersaline environments on the surface of our planet are exposed to the harmful effects of ultraviolet radiation. Therefore, for their protection, they have sunscreen pigments and highly efficient DNA repair and protection ...
María Lamprecht-Grandío, Marta Cortesão, Salvador Mirete, Macarena Benguigui de la Cámara, Carolina G. de Figueras, Danilo Pérez-Pantoja, Joseph John White, María Eugenia Farías, Ramon Rosselló-Móra, José Eduardo González-Pastor   +9 more
doaj   +1 more source

Combination Treatment of TRPV4 Agonist with Cisplatin Promotes Vessel Normalization in an Animal Model of Oral Squamous Cell Carcinoma

Medicina, 2022
Background and Objectives: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in the world. Transient receptor potential vanilloid 4 (TRPV4) channel has been shown to be involved in angiogenesis in multiple types of tumors.
Farhana Yahya, Marina Mohd Bakri, Mohammad Zakir Hossain, Syarifah Nur Syed Abdul Rahman, Aied Mohammed Alabsi, Anand Ramanathan   +5 more
doaj   +1 more source

Reduction of 4-Nitroquinoline 1-Oxide by Microörganisms

Chemical and Pharmaceutical Bulletin, 1962
The ultraviolet absorption maximum of 4-nitroquinoline 1-oxide was shifted toward shorter wave length when the substance was added to the growing media of microorganisms. The investigation of this phenomenon revealed that the shift in ultraviolet absorption maxima is due to the reduction of nitro group at 4-position. It was also foundthat the reduction
Okabayashi, Tadashi, Yoshimoto, Akihiro
openaire   +2 more sources

Yeast Ribonucleotide Reductase Is a Direct Target of the Proteasome and Provides Hyper Resistance to the Carcinogen 4-NQO

Journal of Fungi, 2023
Various external and internal factors damaging DNA constantly disrupt the stability of the genome. Cells use numerous dedicated DNA repair systems to detect damage and restore genomic integrity in a timely manner.
Daria S. Spasskaya, Kirill A. Kulagin, Evgenia N. Grineva, Pamila J. Osipova, Svetlana V. Poddubko, Julia A. Bubis, Elizaveta M. Kazakova, Tomiris T. Kusainova, Vladimir A. Gorshkov, Frank Kjeldsen, Vadim L. Karpov, Irina A. Tarasova, Dmitry S. Karpov   +12 more
doaj   +1 more source

Impact of SLC39A5 Knockout on Establishment of Esophageal Cancer Model Induced by 4-NQO in C57BL/6 Mice

Zhongliu Fangzhi Yanjiu, 2018
Objective To explore the influences of SLC39A5 knockout on the establishment of esophageal cancer model induced by 4-nitroquinoline 1-oxide (4-NQO) in C57BL/6 mice.
WANG Liqun, JIN Jing, LIU Congmin, GAO Zhaoyu, LIANG Di, LI Daojuan, GUO Tiantian, HE Yutong   +7 more
doaj   +1 more source

Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia

Journal of Nanobiotechnology, 2022
Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for malignant transformation. Photosensitizers (PSs) played an indispensable role in the photodynamic therapy (PDT) of OLK, but the poor light sensitivity greatly ...
Lin Lin, Chuanhui Song, Zheng Wei, Huihui Zou, Shengwei Han, Zichen Cao, Xinyu Zhang, Guorong Zhang, Jianchuan Ran, Yu Cai, Wei Han   +10 more
doaj   +1 more source

Generation and Application of Inducible Chimeric RNA ASTN2-PAPPA_as Knockin Mouse Model

Cells, 2022
Chimeric RNAs (chiRNAs) play many previously unrecognized roles in different diseases including cancer. They can not only be used as biomarkers for diagnosis and prognosis of various diseases but also serve as potential therapeutic targets.
Yichen Luo, Liang Du, Zhimeng Yao, Fan Liu, Kai Li, Feifei Li, Jianlin Zhu, Robert P. Coppes, Dianzheng Zhang, Yunlong Pan, Shegan Gao, Hao Zhang   +11 more
doaj   +1 more source

Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice

Frontiers in Immunology, 2023
The herb Prunella vulgaris has shown significant immune-stimulatory and anti-inflammatory effects in mouse models. Here, the effects of a novel Prunella vulgaris-containing herbal mixture, PV-1, were examined in several mouse models for cancer, including
Qi Zhang, Xu Chen, Katie Palen, Bryon Johnson, Dinh Bui, Donghai Xiong, Jing Pan, Ming Hu, Yian Wang, Ming You   +9 more
doaj   +1 more source