Results 11 to 20 of about 3,474 (171)

Impact of Juglone, a PIN1 İnhibitor, on Oral Carcinogenesis Induced by 4-Nitroquinoline-1-Oxide (4NQO) in Rat Model [PDF]

Medicina
Background and Objectives: PIN1 is overexpressed in several human cancers, including prostate cancer, breast cancer, and oral squamous carcinomas. Juglone (J), derived from walnut, was reported to selectively inhibit PIN1 by modifying its sulfhydryl ...
Olgun Topal, Burcu Güçyetmez Topal, Yunus Baş, Bünyamin Ongan, Gökhan Sadi, Esra Aslan, Betül Demirciler Yavaş, Mehmet Bilgehan Pektaş   +7 more
doaj   +2 more sources

Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells. [PDF]

PLoS ONE, 2020
Stilbenes are a group of chemicals characterized with the presence of 1,2-diphenylethylene. Previously, our group has demonstrated that synthesized (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) possesses potential chemopreventive ...
Huan Huan Tan, Noel Francis Thomas, Salmaan Hussain Inayat-Hussain, Kok Meng Chan   +3 more
doaj   +2 more sources

A comparative study of the effects of three modes of 4-Nitroquinoline N-oxide induction of Sprague Dawley rats in animal models of oral leukoplakia [PDF]

Open Life Sciences
Animal models are essential for advancing disease research. However, models for oral leukoplakia (OLK) remain relatively underexplored. This study sought to identify an optimal strategy for establishing a rat OLK model using 4-nitroquinoline 1-oxide ...
Jiao Mengyu, Wang Peiyan, Yu Xiaofei, Yuan Changqing, Sun Pei, Tong Junjie, Wang Tianlu, Deng Jing, Zhang Hui   +8 more
doaj   +2 more sources

Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides [PDF]

Biochemistry, 1978
The interactions of 4-nitroquinoline 1-oxide (NQO) with the four 5'-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and 1H and 13C nuclear magnetic resonance (NMR) spectra of nucleotide-NQO mixtures. Spectral data yielded equilibrium constants (K(dpG:NQO) = 16 M-1, K(dpA:NQO) = 12 M-1, K(dpT:NQO) = K(dpC:NQO) = 4 ...
S A, Winkle, I, Tinoco
openaire   +2 more sources

Fusobacteria modulate oral carcinogenesis and promote cancer progression

Journal of Oral Microbiology, 2021
Background: Evidence suggest periodontal bacterial infection can contribute to oral cancer initiation and progression. Aim: To investigate the effects of periodontal bacteria on oral cancer cell behavior using a cell-based system and a mouse ...
Amani M. Harrandah, Sasanka S. Chukkapalli, Indraneel Bhattacharyya, Ann Progulske-Fox, Edward K. L. Chan   +4 more
doaj   +1 more source

Polyclonal Antibodies to DNA Modified with 4‐Nitroquinoline 1‐Oxide: Application for the Detection of 4‐Nitroquinoline 1‐Oxide‐DNA Adducts in vivo [PDF]

Japanese Journal of Cancer Research, 1988
Antibodies against 4‐nitroquinoline 1‐oxide (4NQO) adducts were elicited in rabbits immunized with 4NQO‐modified DNA complexed with methylated bovine serum albumin. In enzymelinked immunosorbent assay (ELISA), the antibodies could recognize either denatured or native 4NQO‐modified DNA, but not unmodified DNA, DNA modified with other carcinogens or free
Morita, Toshiteru, Ikeda, Sachiya, Minoura, Yasushi, Kojima, Misaki, Tada, Mariko   +4 more
openaire   +2 more sources

Evaluation of the Effect of Two Systemic Doses of HESA-A on Prevention of Induced Tongue Neoplasm in Rats

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
Background and aims. The aim of the present study was to compare the inhibitory effects of two systemic doses of HESA-A on prevention of 4-NQO-induced tongue neoplasms in rats. This study evaluated weight and histopathological changes.
Masoumeh Mehdipour, Ali Taghavi Zenouz, Mehran Mesgari Abbasi, Daryoush Mohajeri, Hossein Damghani, Sanaz Helli, Bita Abdollahi   +6 more
doaj   +1 more source

Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
Constituents of tobacco that can cause DNA adduct formation and oxidative stress are implicated in the development of head and neck squamous cell carcinoma (HNSCC). However, there are few studies on the mechanism(s) that underlie tobacco-associated HNSCC.
Tingting Zhang, Tingting Zhang, Tingting Zhang, Xueqin Zhu, Xueqin Zhu, Qiang Sun, Qiang Sun, Qiang Sun, Xing Qin, Xing Qin, Zhen Zhang, Zhen Zhang, Yuanyong Feng, Ming Yan, Ming Yan, Wantao Chen, Wantao Chen, Wantao Chen   +17 more
doaj   +1 more source

Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway

Frontiers in Oncology, 2019
Taiwanin E is a bioactive compound extracted from Taiwania cryptomerioides Hayata. In this research endeavor, we studied the anti-cancer effect of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cancer cells (OSCC), and ...
Shih-Hao Wang, Shih-Hao Wang, Hsi-Chin Wu, Khan Farheen Badrealam, Yueh-Hsiung Kuo, Yueh-Hsiung Kuo, Yueh-Hsiung Kuo, Yun-Peng Chao, Hsi-Hsien Hsu, Hsi-Hsien Hsu, Da-Tian Bau, Vijaya Padma Viswanadha, Yi-Hui Chen, Pei-Jei Lio, Chung-Jen Chiang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang   +19 more
doaj   +1 more source

Squamous cell carcinoma of the tongue in Sprague-Dawley rats using 4-nitroquinoline 1-oxide model

Padjadjaran Journal of Dentistry, 2016
Background. 4-nitroquinoline 1-oxide (4NQO) is a water soluble carcinogen which is often used to induce cancer in oral cavity. Objective. The purpose of this study was to know the incidence of histopathological lesions in the tongue of rats after ...
Erni Erfan, Nafrialdi N., Puspita Ekawuyung   +2 more
doaj   +1 more source