Results 21 to 30 of about 364 (179)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, Volume 16, Issue 4, Page 788-802, April 2026.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

Structure-Activity Relationships of Nitroarenes: Mutagenicity, Oxygen Consumption, Toxicity, and Xenobiotic Radical Production. [PDF]

, 1997
The nitroreduction of 4NQO and five structural analogs were studied with respect to radical production and mutagenicity. In the umu assay, 4NQO was the most mutagenic analog.
Metosh-dickey, Caroline Ann
core   +2 more sources

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, Volume 117, Issue 4, Page 1010-1025, April 2026.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 618-628, March 2026.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, Volume 46, Issue 3, Page 950-960, March 2026.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Synthesis of heterocyclic bases derived from m-phenanthroline of possible antimalarial activity [PDF]

, 1941
#I. A survey of the literature dealing with antimalarial compounds is given, with special reference to the relationship between chemotherapeutic activity and chemical constitution. #II.
Webster, William
core  

FBXW7 Targets the SPT6‐ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4‐Nitroquinoline N‐Oxide

MedComm, Volume 7, Issue 3, March 2026.
In normal cells, FBXW7 promotes ubiquitylation and degradation of SPT6 and ΔNp63 to keep their pro‐proliferative functions under control. During esophageal tumorigenesis, FBXW7 is inactivated by mutations or deletion, leading to the accumulation of SPT6 and ΔNp63, with ΔNp63 also being up‐regulated by SPT6.
Jiagui Zhang, Lu Yin, Xiahong You, Xiufang Xiong, Yi Sun   +4 more
wiley   +1 more source

Latest Advancements in Using Fe3O4@graphene Oxide Nanocatalyst for the Hydrogenation of Nitroarenes

ChemistryOpen, Volume 15, Issue 3, March 2026.
This review provides a comprehensive summary of recent advances in Fe3O4@graphene oxide magnetic nanocatalysts for the reduction of nitroarenes. The reduction of nitroarenes yields valuable intermediates that serve as key building blocks in the synthesis of agrochemicals and pharmaceuticals.
Sara Payamifar, Majid Abdouss, Hamideh Sarreshtehdar Aslaheh, Ahmad Poursattar Marjani   +3 more
wiley   +1 more source