Results 131 to 140 of about 709 (171)
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A comparative study on the genetic effects of hycanthone and oxamniquine
Journal of Toxicology and Environmental Health, 1975Oxamniquine (UK-4271; 6-hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline) is a new schistosomicidal agent currently undergoing clinical investigation in South America. Essentially a complete cure rate against Brazilian Schistosoma mansoni has been seen in adults with a single im dose of 7.5 mg/kg or a single oral dose of 15 mg ...
V A, Ray +3 more
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Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine
Bioorganic & Medicinal Chemistry, 2017Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in poverty conditions, contribute to the maintenance of social inequality, being a strong barrier to a country development. Schistosomiasis, a NTD, is a tropical and subtropical disease caused by the trematode Schistosoma mansoni (Africa, Middle East, Caribbean, Brazil,
VinÃcius Barros Ribeiro da Silva +4 more
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The treatment of experimental schistosomiasis with a combination of oxamniquine and praziquantel
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983The object of the study was to identify any potential therapeutic advantage in using the two antischistosomal drugs, oxamniquine and praziquantel, in combination rather than separately, in the treatment of schistosomiasis. The efficacy of the drugs was studied in albino mice with mature Schistosoma mansoni infections.
J R, Shaw, K W, Brammer
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2017
Oxamniquine (Mansil and Vansil, from Pfizer)-developed as UK 4271-was first described in 1969 (Richards and Foster, 1969) as a metabolite of a compound then known as UK3883(2-isopropylami-nomethyl-6-methyl-7-nitro-1,2,3,4- tetrahydroquinoline). Oxamniquine is 1,2,3,4-tetrahydro- 2-isopropylaminomethyl-7-nitro-6-quinolylmethanol.
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Oxamniquine (Mansil and Vansil, from Pfizer)-developed as UK 4271-was first described in 1969 (Richards and Foster, 1969) as a metabolite of a compound then known as UK3883(2-isopropylami-nomethyl-6-methyl-7-nitro-1,2,3,4- tetrahydroquinoline). Oxamniquine is 1,2,3,4-tetrahydro- 2-isopropylaminomethyl-7-nitro-6-quinolylmethanol.
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Effects of oxamniquine on neuromuscular transmission.
Archives internationales de pharmacodynamie et de therapie, 1985The effects of oxamniquine on neuromuscular transmission have been investigated in some experimental animals in an effort to unveil some of the unwanted effects of this commonly prescribed schistosomicide. Results obtained show that relatively low concentrations of the drug (oxamniquine, 10-100 micrograms/ml) potentiated acetylcholine-, carbachol- and ...
C O, Adewunmi, J A, Ojewole
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
H, Stokvis +4 more
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H, Stokvis +4 more
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