Pharmacological and pharmacokinetic studies on trematocidal drugs : praziquantel and two synthetic peroxide lead candidates [PDF]
Trematodiases affect more than 250 million people worldwide, while the economic impact through veterinary infections is also colossal. Treatment options are however limited to two main drugs, triclabendazole for the liver fluke Fasciola hepatica, and ...
Meister, Isabel
core +1 more source
Kinetics of the cercaria-schistosomul um transformation in vivo: 2. The effect of oxamniquine
To study the cercaria-schistosomulum transformation in vivo, underthe influence of an antischistosomal compound (oxamniquine), a model using cercarial infections into the abdominal cavity of mice was chosen.
A. L. Melo, L.H. Pereira
doaj +3 more sources
Basofilia e anisotropia nucleares em células de camundongo após tratamento com oxamniquine
Com o objetivo de se estudar a ação da oxamniquine, uma droga utilizada no tratamento da esquistossomose, sobre a cromatina de núcleos de células animais, foram estudados os padrões de basofilia e anisotropia nucleares em hepatócitos, em células do ...
Ivanira José Bechara +1 more
doaj +1 more source
Tratamento da esquistossomose com oxamniquine (xarope) em crianças
Foram tratados pela oxamniquine, sob a forma de xarope, 75 esquistossomôticos. com idade de 3 a 12 anos, distribuídos uniformente por quatro grupos, utilizando-se os esquemas de 15, 20 e 25 mg por quilo de peso corporal, em dose única e 20mg subdivididos
J. C. Bina, A. Prata
doaj +3 more sources
Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa. [PDF]
Human Immunodeficiency Virus-1/AIDS and Schistosoma mansoni are widespread in sub-Saharan Africa and co-infection occurs commonly. Since the early 1990s, it has been suggested that the two infections may interact and potentiate the effects of each other ...
A Cossarizza +124 more
core +4 more sources
Eficácia terapêutica da oxamniquine oral no tratamento da salmonelose septicêmica prolongada
Trinta e cinco pacientes com salmonelose septicêmica prolongada (SSP) foram selecionados para o estudo. Vinte (Grupo 1), foram tratados com a oxamniquine oral (15-20mg/kg de peso, dose única) e 15 (Grupo 2) com o cloranfenicol (50mg/kg de peso/15-20 dias)
José Roberto Lambertucci +4 more
doaj +1 more source
25 years of the WHO essential medicines lists: progress and challenges. [PDF]
The first WHO essential drugs list, published in 1977, was described as a peaceful revolution in international public health. The list helped to establish the principle that some medicines were more useful than others and that essential medicines were ...
't Hoen +22 more
core +1 more source
Physicochemical interactions of praziquantel, oxamniquine and tablet excipients
Abstract A differential scanning calorimetry and infrared spectrophotometry study of potential interactions between oxamniquine and praziquantel, two synergistic anti-parasitic drugs, indicated that they did not interact on fusion.
R J, Prankerd, S M, Ahmed
openaire +2 more sources
Schistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent ...
Sevan N. Alwan +4 more
doaj +1 more source

