Results 61 to 70 of about 1,239 (187)
Synthesis and biological activity of 6-formyl-oxamniquine derivative
, 2015 Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl-
Allegretti, SM +6 more
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PLoS Neglected Tropical Diseases, 2020 Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals ...
Meghan A Guzman +11 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2007 Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE.
Joelma R de Souza +8 more
doaj
Parasites & Vectors, 2018 Background Schistosomiasis is one of the most harmful parasitic diseases worldwide, praziquantel being the only drug in widespread use to treat it. We recently demonstrated that ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine (Fc-OXA, Rc ...
Valentin Buchter +3 more
doaj +1 more source
Physicochemical interactions of praziquantel, oxamniquine and tablet excipients
Journal of Pharmacy and Pharmacology, 1992 Abstract A differential scanning calorimetry and infrared spectrophotometry study of potential interactions between oxamniquine and praziquantel, two synergistic anti-parasitic drugs, indicated that they did not interact on fusion.
R J, Prankerd, S M, Ahmed
openaire +2 more sources
Similar cellular responses after treatment with either praziquantel or oxamniquine in Schistosoma mansoni infection. [PDF]
, 2009 The effect of treatment with either oxamniquine or praziquantel on S. mansoni specific IFN-gamma, IL-4, IL-5 and IL-10 was compared on PBMC which were collected pretreatment, 6 and 18 weeks post treatment.
T Mduluza +18 more
core +1 more source
Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population [PDF]
, 2016 Molecular surveillance provides a powerful approach to monitoring the resistance status of parasite populations in the field and for understanding resistance evolution.
Rugel, Anastasia R. +11 more
core +1 more source
The immune-dependence of chemotherapy in experimental schistosomiasis
Memorias do Instituto Oswaldo Cruz, 1989 Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by ...
M. J. Doenhoff
doaj +1 more source
Cardiac arrhythmia with oral oxamniquine in the treatment of schistosomiasis mansoni
, 1993 Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
Baldy, José Luis da Silveira +2 more
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Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni
, 2017 The antischistosomal activity of clonazepam, when administered alone or in association with oxamniquine and praziquantel, was experimentally evaluated in mice infected with Schistosoma mansoni.
Katz, Naftale +3 more
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