Results 41 to 50 of about 1,461 (168)
ChemMedChem, Volume 20, Issue 23, November 28, 2025.Novel organometallic derivatives of niridazole are designed, synthesized, and tested against Schistosoma mansoni. Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ).
Tanja Karpstein +10 more
wiley +1 more source
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400 μg/mL)
Rodrigo Luiz Fabri +10 more
wiley +1 more source
, 2014 Human schistosomiasis-or bilharzia-is a parasitic disease caused by trematode fl ukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp.
Bustinduy, Amaya L +3 more
core +1 more source
ChemMedChem, Volume 20, Issue 6, March 15, 2025.The present study describes the synthesis and thorough investigation of 1,2,3‐triazole‐methyl‐menadione derivatives with particular emphasis on their electrochemical and physicochemical properties and their antiparasitic activities against Plasmodium falciparum and Schistosoma mansoni. Although less effective against P.
Baptiste Dupouy +8 more
wiley +1 more source
Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014 Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug resistance.
Sonam Gaba +4 more
wiley +1 more source
Treatment of schistosomiasis: gathering stones together
Memorias do Instituto Oswaldo Cruz, 1995 In this paper the treatment of schistosomiasis is examined under the following headings: cercarial dermatitis, Katayama fever, schistosomiasis in the immunosuppressed host and treatment of therapeutic failures.
J. R. Lambertucci
doaj +1 more source
Hybridisations within the genus Schistosoma: implications for evolution, epidemiology and control [PDF]
, 2016 SUMMARYHybridization of parasites is an emerging public health concern in our changing world. Hybridization and introgression in parasites and pathogens can have major impacts on the host and the epidemiology and evolution of disease.
Leger, E, Webster, J P
core +2 more sources
Ruthenium Catalysed Transfer Deuteration of Heteroaromatics in D2O
Asian Journal of Organic Chemistry, Volume 14, Issue 1, January 2025.The partial reduction of heterocycles with selective deuterium incorporation using formic acid/sodium formate, D2O and a ruthenium catalyst was achieved. A biphasic medium (toluene/D2O) allowed excellent catalyst recycling. The ruthenium center allowed an inversion of polarity of D+ that was transformed into deuteride.
Carlos Gonzalo‐Navarro +5 more
wiley +1 more source
Enantioselective Synthesis of Tetrahydroquinoline Alkaloids (-)-Angustureine and (-)-Cuspareine from Chiral tert-Butanesulfinyl Imines [PDF]
, 2014 The addition of a Grignard reagent to both enantiomeric N-tert-butanesulfinyl imines derived from 3-(2-bromophenyl)propanal 8 proceeded with high diastereoselectivity.
Foubelo, Francisco +2 more
core +2 more sources
Antimicrobial Multidrug Resistance and Mechanisms of Action: An Overview
BioMed Research International, Volume 2025, Issue 1, 2025.Antimicrobial multidrug resistance is the ability of microorganisms to withstand the effects of several antimicrobial agents, presenting a major challenge to modern healthcare systems worldwide. Although considerable research has been conducted, the molecular and evolutionary mechanisms underlying resistance are still not completely understood.
Abraham Belete Temesgen +2 more
wiley +1 more source