Results 21 to 30 of about 1,239 (187)

Eficácia terapêutica da oxamniquine oral no tratamento da salmonelose septicêmica prolongada [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1985
Trinta e cinco pacientes com salmonelose septicêmica prolongada (SSP) foram selecionados para o estudo. Vinte (Grupo 1), foram tratados com a oxamniquine oral (15-20mg/kg de peso, dose única) e 15 (Grupo 2) com o cloranfenicol (50mg/kg de peso/15-20 dias)
José Roberto Lambertucci, Roberto Pedercini Marinho, Maria das Dores Ferreira, Jayme Neves, Ênio Roberto Pietra Pedroso   +4 more
doaj   +2 more sources

Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine

Memorias do Instituto Oswaldo Cruz, 2000
After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis.
Maria José Conceição, Carlos Alberto Argento, Acyr Corrêa   +2 more
doaj   +2 more sources

Persistent Vulvar Itch Unresponsive to Treatment: A Case of Vulvar Schistosomiasis Caused by Schistosoma mansoni and a Brief Review of Literature. [PDF]

Case Rep Infect Dis, 2023
Background. Vulvar schistosomiasis is a female genital schistosomiasis (FGS), which occurs because of the damage caused by the presence of schistosome ova within the vulva. FGS is mostly misdiagnosed as a sexually transmitted infection. There is no reported case of vulvar schistosomiasis from Schistosoma mansoni in an immunocompetent or ...
Gyening-Yeboah A, Quayson SE.
europepmc   +2 more sources

Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. [PDF]

ChemMedChem
Novel organometallic derivatives of niridazole are designed, synthesized, and tested against Schistosoma mansoni. Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ).
Karpstein T, Zhong S, Keller S, Späne P, Häberli C, Panic G, Blacque O, Odermatt A, Cariou K, Gasser G, Keiser J.   +10 more
europepmc   +2 more sources

Aspects of the biological activity of the schistosomicide oxamniquine

, 1992
Oxamniquine, 6-hydroxymethyl-2-N-isopropylaminomethyl-7-nitro-1,2,3,4- tetrahydroquinoline, is a potent schistosomicide used clinically in the treatment of infections due to Schistosoma mansoni.
Catherine W. Karekezi (7166537)
core   +6 more sources

Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial

Bulletin of the World Health Organization, 2003
OBJECTIVE: To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide drugs, and to compare the accuracy of faecal examination with the accuracy of oogram in testing for Schistosoma mansoni ...
Ferrari M.L.A., Coelho P.M.Z., Antunes C.M.F., Tavares C.A.P., Cunha A.S. da   +4 more
doaj   +1 more source

The role of the host gut microbiome in the pathophysiology of schistosomiasis

Parasite Immunology, Volume 45, Issue 4, April 2023., 2023
Abstract The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg‐induced granulomas is the result of finely regulated crosstalk ...
Klara A. Stark, Gabriel Rinaldi, Alba Cortés, Alice Costain, Andrew S. MacDonald, Cinzia Cantacessi   +5 more
wiley   +1 more source

Estudo da ação "in vitro" da Oxamniquine sobre bactérias do gênero Salmonella

Revista da Sociedade Brasileira de Medicina Tropical, 1976
Os autores estudaram a ação "in vitro" da oxamniquine sobre dez espécies de salmonelas. Verificaram que diluições de 1,56 a 400 mcg/ml não exerceram qualquer efeito no crescimento bacteriano. Estas observações têm implicações no tratamento da salmonelose
Vicente Amato Neto, Maria Lúcia Ribeiro da Silva, Luiz Jacintho da Silva, Maria Lúcia Bortoletto   +3 more
doaj   +2 more sources

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**

ChemistryOpen, Volume 11, Issue 2, February 2022., 2022
Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Tamara Todorovic, Radivoje Prodanovic, Veljko Veljkovic, Slobodan Paessler, Sanja Glisic   +7 more
wiley   +1 more source

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 1136-1146, April 2021., 2021
The intestinal epithelium represents a natural barrier against harmful xenobiotics, while facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and ...
Zubida M. Al‐Majdoub, Narciso Couto, Brahim Achour, Matthew D. Harwood, Gordon Carlson, Geoffrey Warhurst, Jill Barber, Amin Rostami‐Hodjegan   +7 more
wiley   +1 more source