The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase
Memorias do Instituto Oswaldo Cruz, 2006 Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites.
Livia Pica-Mattoccia +5 more
doaj +1 more source
Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel
Memorias do Instituto Oswaldo Cruz, 2002 The susceptibility of a fourth generation Ouh strain (Paranapanema Valley, São Paulo, Brazil) of Schistosoma mansoni to oxamniquine (OXA) and praziquantel (PZQ) was studied.
Patrícia Ivana Pires Bonesso-Sabadini +1 more
doaj +1 more source
Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents
Memorias do Instituto Oswaldo Cruz, 1993 The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice.
Kristen M. Drescher +5 more
doaj +1 more source
In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine [PDF]
, 2014 BACKGROUND: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S.
Dakir, E L Habib +5 more
core +3 more sources
Schistosoma mansoni: Antiparasitic effects of orally administered Nigella sativa oil and/or Chroococcus turgidus extract [PDF]
, 2016 Schistosoma mansoni is one of the parasites causing schistosomiasis, a disease which threatens millions of people all over the world. Traditional chemical drugs are not fully effective against schistosomaisis due to the evolving drug resistant worm ...
Ali, Medhat +3 more
core +1 more source
Rate of action of schistosomicides in mice infected with Schistosoma mansoni
Revista da Sociedade Brasileira de Medicina Tropical, 1989 Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel.
Naftale Katz +4 more
doaj +3 more sources
Acute schistosomiasis, a diagnostic and therapeutic challenge [PDF]
, 2010 In non-endemic countries, acute (invasive) schistosomiasis (AS) is typically seen in non-immune travellers, whereas chronic schistosomiasis is more frequently diagnosed in immigrants.
Jauréguiberry, S. +2 more
core +1 more source
Oxamniquine Derivatives Overcome Praziquantel Treatment Limitations for Schistosomiasis
PLOS Pathogens, 2023 AbstractHuman schistosomiasis is a neglected tropical disease caused bySchistosoma mansoni, S. haematobium,andS. japonicum.Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new therapies for schistosomiasis. Previous treatment ofS.
Sevan N. Alwan +5 more
openaire +3 more sources
Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
Memorias do Instituto Oswaldo Cruz, 2000 After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis.
Maria José Conceição +2 more
doaj +1 more source
Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate
BioMed Research International, Volume 2016, Issue 1, 2016., 2016 Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae
Yufan Cao +9 more
wiley +1 more source