Results 1 to 10 of about 709 (171)

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species [PDF]

Pharmaceutics
Schistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent ...
Sevan N. Alwan, Alexander B. Taylor, Stanton F. McHardy, Michael D. Cameron, Philip T. LoVerde   +4 more
doaj   +2 more sources

Resistance of schistosomes to hycanthone and oxamniquine [PDF]

Memorias do Instituto Oswaldo Cruz, 1989
Genetic crosses between phenotypically resistant and sensitive schistosomes demonstrated that resistance to hycanthone and oxamniquine behaves like a recessive trait, thus suggesting that resistance is due to the lack of some factor. We hypothesized that,
Donato Cioli, Livia Pica-Mattoccia, Sydney Archer   +2 more
doaj   +4 more sources

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans. [PDF]

PLoS Neglected Tropical Diseases, 2020
Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading to the necessity for additional pharmaceuticals ...
Meghan A Guzman, Anastasia R Rugel, Reid S Tarpley, Sevan N Alwan, Frédéric D Chevalier, Dmytro P Kovalskyy, Xiaohang Cao, Stephen P Holloway, Timothy J C Anderson, Alexander B Taylor, Stanton F McHardy, Philip T LoVerde   +11 more
doaj   +2 more sources

Baixa eficácia da associação oxamniquine e praziquantel na cura da esquistossomose mansônica

Revista da Sociedade Brasileira de Medicina Tropical, 1986
Em uma área endêmica onde havia interrupção da transmissão, foram tratados 164 esquistossomóticos com a associação oxamniquine e praziquantel em doses reduzidas.
R. Dietze, A. Prata
doaj   +3 more sources

Comparação entre praziquantel e oxamniquine no tratamento da esquistossomose mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1983
Tratamos 120 pacientes masculinos com idade de 17 a 19 anos, portadores de esquistossomose mansoni nas formas intestinal e hepatointestinal, pareados de acordo com o número de ovos por grama de fezes.
Antônio Emanuel, Aluízio Prata
doaj   +3 more sources

Variation in response of Schistosoma mansoni strains to schistosomicides

Revista do Instituto de Medicina Tropical de São Paulo, 1988
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is ...
Luiz Cândido de Souza Dias, John I. Bruce, Gerald C. Coles   +2 more
doaj   +1 more source

Survey on the clinical trial results achieved in Brazil comparing praziquantel and oxamniquine in the treatment of mansoni schistosomiasis

Revista do Instituto de Medicina Tropical de São Paulo, 1985
A random, double-blind, parallel group clinical trial program was carried out to compare praziquantel, a recently developed anti-helmintic drug, and oxamniquine, an already established agent for treating mansoni schistosomiasis.
Getúlio Leonel de Rezende
doaj   +1 more source

Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1976
Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S.
Maria Zelia Rouquayrol, Y.M. Almeida, E.G. Oliveira, Z.F. Silva, V.A.M. Pinto, J.E. Alencar   +5 more
doaj   +3 more sources

Arritmia cardíaca com uso de oxamniquine oral no tratamento de esquistossomose mansônica Cardiac arrhythmia with oral oxamniquine in the treatment of schistosomiasis mansoni

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
José Carlos dos Santos Guitti, Lúcio Navarro Gordan, José Luis da Silveira Baldy   +2 more
doaj   +1 more source

Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 1987
A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of ...
K. Zwingenberger, J. A. Nogueira Queiroz, U. Poggensee, J. E. Alencar, J. Valdegunas, F. Esmeralda, H. Feldmeier   +6 more
doaj   +1 more source