Results 1 to 10 of about 663 (111)

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species [PDF]

Pharmaceutics
Schistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent ...
Sevan N. Alwan, Alexander B. Taylor, Stanton F. McHardy, Michael D. Cameron, Philip T. LoVerde   +4 more
doaj   +2 more sources

Baixa eficácia da associação oxamniquine e praziquantel na cura da esquistossomose mansônica

Revista da Sociedade Brasileira de Medicina Tropical, 1986
Em uma área endêmica onde havia interrupção da transmissão, foram tratados 164 esquistossomóticos com a associação oxamniquine e praziquantel em doses reduzidas.
R. Dietze, A. Prata
doaj   +3 more sources

Variation in response of Schistosoma mansoni strains to schistosomicides

Revista do Instituto de Medicina Tropical de São Paulo, 1988
The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is ...
Luiz Cândido de Souza Dias, John I. Bruce, Gerald C. Coles   +2 more
doaj   +1 more source

Survey on the clinical trial results achieved in Brazil comparing praziquantel and oxamniquine in the treatment of mansoni schistosomiasis

Revista do Instituto de Medicina Tropical de São Paulo, 1985
A random, double-blind, parallel group clinical trial program was carried out to compare praziquantel, a recently developed anti-helmintic drug, and oxamniquine, an already established agent for treating mansoni schistosomiasis.
Getúlio Leonel de Rezende
doaj   +1 more source

Comparação entre praziquantel e oxamniquine no tratamento da esquistossomose mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1983
Tratamos 120 pacientes masculinos com idade de 17 a 19 anos, portadores de esquistossomose mansoni nas formas intestinal e hepatointestinal, pareados de acordo com o número de ovos por grama de fezes.
Antônio Emanuel, Aluízio Prata
doaj   +3 more sources

Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1976
Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S.
Maria Zelia Rouquayrol, Y.M. Almeida, E.G. Oliveira, Z.F. Silva, V.A.M. Pinto, J.E. Alencar   +5 more
doaj   +3 more sources

Arritmia cardíaca com uso de oxamniquine oral no tratamento de esquistossomose mansônica Cardiac arrhythmia with oral oxamniquine in the treatment of schistosomiasis mansoni

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
José Carlos dos Santos Guitti, Lúcio Navarro Gordan, José Luis da Silveira Baldy   +2 more
doaj   +1 more source

Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 1987
A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of ...
K. Zwingenberger, J. A. Nogueira Queiroz, U. Poggensee, J. E. Alencar, J. Valdegunas, F. Esmeralda, H. Feldmeier   +6 more
doaj   +1 more source

The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase

Memorias do Instituto Oswaldo Cruz, 2006
Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites.
Livia Pica-Mattoccia, Daniele Carlini, Alessandra Guidi, Velasco Cimica, Fabio Vigorosi, Donato Cioli   +5 more
doaj   +1 more source

Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel

Memorias do Instituto Oswaldo Cruz, 2002
The susceptibility of a fourth generation Ouh strain (Paranapanema Valley, São Paulo, Brazil) of Schistosoma mansoni to oxamniquine (OXA) and praziquantel (PZQ) was studied.
Patrícia Ivana Pires Bonesso-Sabadini, Luiz Cândido de Souza Dias   +1 more
doaj   +1 more source