Results 11 to 20 of about 1,461 (168)

The role of the host gut microbiome in the pathophysiology of schistosomiasis

Parasite Immunology, Volume 45, Issue 4, April 2023., 2023
Abstract The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg‐induced granulomas is the result of finely regulated crosstalk ...
Klara A. Stark, Gabriel Rinaldi, Alba Cortés, Alice Costain, Andrew S. MacDonald, Cinzia Cantacessi   +5 more
wiley   +1 more source

Persistent Vulvar Itch Unresponsive to Treatment: A Case of Vulvar Schistosomiasis Caused by Schistosoma mansoni and a Brief Review of Literature

Case Reports in Infectious Diseases, Volume 2023, Issue 1, 2023., 2023
Background. Vulvar schistosomiasis is a female genital schistosomiasis (FGS), which occurs because of the damage caused by the presence of schistosome ova within the vulva. FGS is mostly misdiagnosed as a sexually transmitted infection. There is no reported case of vulvar schistosomiasis from Schistosoma mansoni in an immunocompetent or ...
Anthony Gyening-Yeboah, Solomon E. Quayson, Mohamed A. Dkhil   +2 more
wiley   +1 more source

Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**

ChemistryOpen, Volume 11, Issue 2, February 2022., 2022
Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski, Vladimir Perovic, Jelena Milicevic, Tamara Todorovic, Radivoje Prodanovic, Veljko Veljkovic, Slobodan Paessler, Sanja Glisic   +7 more
wiley   +1 more source

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 1136-1146, April 2021., 2021
The intestinal epithelium represents a natural barrier against harmful xenobiotics, while facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and ...
Zubida M. Al‐Majdoub, Narciso Couto, Brahim Achour, Matthew D. Harwood, Gordon Carlson, Geoffrey Warhurst, Jill Barber, Amin Rostami‐Hodjegan   +7 more
wiley   +1 more source

Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1976
Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S.
Maria Zelia Rouquayrol, Y.M. Almeida, E.G. Oliveira, Z.F. Silva, V.A.M. Pinto, J.E. Alencar   +5 more
doaj   +3 more sources

Arritmia cardíaca com uso de oxamniquine oral no tratamento de esquistossomose mansônica Cardiac arrhythmia with oral oxamniquine in the treatment of schistosomiasis mansoni

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Os autores relatam caso clínico de paciente com esquistossomose mansônica, tratado com oxamniquine oral em dose única de 15 mg/kg, que apresenta como efeito colateral um bloqueio átrio-ventricular incompleto tipo Mobitz I, com parada sinusal e escape ...
José Carlos dos Santos Guitti, Lúcio Navarro Gordan, José Luis da Silveira Baldy   +2 more
doaj   +1 more source

Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments

Chemistry – A European Journal, Volume 26, Issue 40, Page 8676-8688, July 17, 2020., 2020
There is an urgent clinical need for new agents to treat microbial infections and cancer, especially to combat resistance to current drugs. The successful strategy of conjugating existing drugs to organometallic fragments is illustrated with examples of conjugated organometallic metallocene sandwich and half‐sandwich complexes, especially ferrocene ...
Prinessa Chellan, Peter J. Sadler
wiley   +1 more source

Tratamento da esquitossomose mansoni pela oxamniquine em dose única, pela via oral [PDF]

, 1976
A oxamniquine em cápsulas foi usada no tratamento de 132 doentes com esquistossomose mansoni crônica, sendo 129 com a forma hepato-intestinal e 3 com a forma hepato-esplênica.
Figueiredo, José Fernando M., Lauria, Liana, Prata, Aluizio, Senna, Plínio Garcez de   +3 more
core   +3 more sources

Drug repositioning : a machine-learning approach through data integration [PDF]

, 2013
Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels.
D'Amato, Mauro, Greco, Dario, Kere, Juha, Moreira, Vânia M, Napolitano, Francesco, Tagliaferri, Roberto, Zhao, Yan   +6 more
core   +1 more source

Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 1987
A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of ...
K. Zwingenberger, J. A. Nogueira Queiroz, U. Poggensee, J. E. Alencar, J. Valdegunas, F. Esmeralda, H. Feldmeier   +6 more
doaj   +1 more source