Results 11 to 20 of about 709 (171)
Persistent Vulvar Itch Unresponsive to Treatment: A Case of Vulvar Schistosomiasis Caused by Schistosoma mansoni and a Brief Review of Literature. [PDF]
Case Rep Infect Dis, 2023 Background. Vulvar schistosomiasis is a female genital schistosomiasis (FGS), which occurs because of the damage caused by the presence of schistosome ova within the vulva. FGS is mostly misdiagnosed as a sexually transmitted infection. There is no reported case of vulvar schistosomiasis from Schistosoma mansoni in an immunocompetent or ...
Gyening-Yeboah A, Quayson SE.
europepmc +2 more sources
Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis. [PDF]
ChemMedChemNovel organometallic derivatives of niridazole are designed, synthesized, and tested against Schistosoma mansoni. Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ).
Karpstein T +10 more
europepmc +2 more sources
The role of the host gut microbiome in the pathophysiology of schistosomiasis
Parasite Immunology, Volume 45, Issue 4, April 2023., 2023 Abstract The pathophysiology of schistosomiasis is linked to the formation of fibrous granulomas around eggs that become trapped in host tissues, particularly the intestines and liver, during their migration to reach the lumen of the vertebrate gut. While the development of Schistosoma egg‐induced granulomas is the result of finely regulated crosstalk ...
Klara A. Stark +5 more
wiley +1 more source
ChemistryOpen, Volume 11, Issue 2, February 2022., 2022 Combined in silico machinery, consisting of long‐ and short‐range molecular interaction methods is capable of filtering large compound databases, yielding a good candidate for a receptor. The advantage of this approach is a fast assessment of a candidate, starting from basic information on both protein and small organic molecule – FASTA sequence and ...
Milan Sencanski +7 more
wiley +1 more source
Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics
Clinical Pharmacology &Therapeutics, Volume 109, Issue 4, Page 1136-1146, April 2021., 2021 The intestinal epithelium represents a natural barrier against harmful xenobiotics, while facilitating the uptake of nutrients and other substances. Understanding the interaction of chemicals with constituents of the intestinal epithelium and their fate in the body requires quantitative measurement of relevant proteins in in vitro systems and ...
Zubida M. Al‐Majdoub +7 more
wiley +1 more source
Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments
Chemistry – A European Journal, Volume 26, Issue 40, Page 8676-8688, July 17, 2020., 2020 There is an urgent clinical need for new agents to treat microbial infections and cancer, especially to combat resistance to current drugs. The successful strategy of conjugating existing drugs to organometallic fragments is illustrated with examples of conjugated organometallic metallocene sandwich and half‐sandwich complexes, especially ferrocene ...
Prinessa Chellan, Peter J. Sadler
wiley +1 more source
The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase
Memorias do Instituto Oswaldo Cruz, 2006 Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites.
Livia Pica-Mattoccia +5 more
doaj +1 more source
Altered Response of Strain of Schistosoma mansoni to Oxamniquine and Praziquantel
Memorias do Instituto Oswaldo Cruz, 2002 The susceptibility of a fourth generation Ouh strain (Paranapanema Valley, São Paulo, Brazil) of Schistosoma mansoni to oxamniquine (OXA) and praziquantel (PZQ) was studied.
Patrícia Ivana Pires Bonesso-Sabadini +1 more
doaj +1 more source
Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents
Memorias do Instituto Oswaldo Cruz, 1993 The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice.
Kristen M. Drescher +5 more
doaj +1 more source
Rate of action of schistosomicides in mice infected with Schistosoma mansoni
Revista da Sociedade Brasileira de Medicina Tropical, 1989 Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel.
Naftale Katz +4 more
doaj +3 more sources