Results 31 to 40 of about 1,239 (187)

Enhancing the Activity of Drugs by Conjugation to Organometallic Fragments

Chemistry – A European Journal, Volume 26, Issue 40, Page 8676-8688, July 17, 2020., 2020
There is an urgent clinical need for new agents to treat microbial infections and cancer, especially to combat resistance to current drugs. The successful strategy of conjugating existing drugs to organometallic fragments is illustrated with examples of conjugated organometallic metallocene sandwich and half‐sandwich complexes, especially ferrocene ...
Prinessa Chellan, Peter J. Sadler
wiley   +1 more source

Dose-response curve for oxamniquine.

, 2023
Normalized animal lengths (y-axis) are plotted for each strain as a function of the dose of oxamniquine in the high-throughput microscopy assay (x-axis). Strains are denoted by color. Lines extending from points represent the standard deviations from the
Clayton M. Dilks (15085737), Timothy A. Crombie (4377244), Hanchen Li (630842), Raffi V. Aroian (103098), Janneke Wit (736160), Erik C. Andersen (6807304), Amanda O. Shaver (3263472)   +6 more
core   +1 more source

Synthesis and biological activity of 6-formyl-oxamniquine derivative [PDF]

, 2008
Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl-
Almeida, Adelia Emilia de, De Souza, Ana Luiza Ribeiro [UNESP], Allegretti, Silmara Marques, De Souza, Ana Luiza Ribeiro, Pinto, Mara Cristina [UNESP], De Souza A.L.R., De Almeida A.E., Allegretti S.M., Chin, Chung Man, Frezza T.F., Pinto, Mara Cristina, Chung, Man Chin, Ferreira, Antônio Gilberto, Man C.C., Frezza, Tarsila Ferraz, Pinto M.C., Chin, Chung Man [UNESP], Almeida, Adelia Emilia de [UNESP], Souza, Ana Luiza Ribeiro de, Ferreira A.G.   +19 more
core   +1 more source

Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents

Memorias do Instituto Oswaldo Cruz, 1993
The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice.
Kristen M. Drescher, Eugene J. Rogers, John I. Bruce, Naftale Katz, Luiz Candido de Souza Dias, Gerald C. Coles   +5 more
doaj   +1 more source

Rate of action of schistosomicides in mice infected with Schistosoma mansoni

Revista da Sociedade Brasileira de Medicina Tropical, 1989
Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel.
Naftale Katz, Emmanuel Pinto Dias, Cecilia Pereira de Souza, John I. Bruce, Gerald C. Coles   +4 more
doaj   +3 more sources

Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae
Yufan Cao, Hongbin Qiao, Yanli Shi, Yu Han, Jinming Liu, Hao Li, Ke Lu, Jiaojiao Lin, Yamei Jin, David Piedrafita   +9 more
wiley   +1 more source

Separation of oxamniquine stereoisomers by capillary zone electrophoresis.

, 2015
Top: profile of racemic oxamniquine alone. Bottom: profile of racemic oxamniquine spiked with isomer #1 (arrow) purified by HPLC.
Chiara M. Polcaro (815899), Alexander B. Taylor (815897), Enrica Donati (815900), Stephen P. Holloway (815903), Xiaohang Cao (815901), Annalisa Basso (257729), Timothy J. C. Anderson (250160), Philip T. LoVerde (188717), Donato Cioli (815905), Livia Pica-Mattoccia (815898), P. John Hart (815904), Alessandra Guidi (146927), Anastasia R. Rugel (815902)   +12 more
core   +1 more source

Deworming and adjuvant interventions for improving the developmental health and well‐being of children in low‐ and middle‐income countries: a systematic review and network meta‐analysis

Campbell Systematic Reviews, Volume 12, Issue 1, Page 1-383, 2016., 2016
This review evaluates the effects of mass deworming for soil‐transmitted helminths on growth, educational achievement, cognition, school attendance, quality of life and adverse effects in children in endemic helminth areas. Mass deworming for soil‐transmitted helminths probably has little to no effect on weight, height, school attendance, cognition ...
Vivian A. Welch, Elizabeth Ghogomu, Alomgir Hossain, Shally Awasthi, Zulfi Bhutta, Chisa Cumberbatch, Robert Fletcher, Jessie McGowan, Shari Krishnaratne, Elizabeth Kristjansson, Salim Sohani, Shalini Suresh, Peter Tugwell, Howard White, George Wells   +14 more
wiley   +1 more source

Contribuição da presença do eosinofilo no escarro ao diagnóstico das alterações pulmonares pós-tratamento na esquistossomose mansoni humana crônica: estudo duplo-cego

Revista da Sociedade Brasileira de Medicina Tropical, 1984
Em estudo duplo-cego observou-se que as alterações radiológicaspulmonares após tratamento com oxamniquine de pacientes com esquistossomose mansoni crônica associam-se com a presença de eosinófilos no escarro (pIn a double-blind study, thepost-oxamniquine
Ênio Roberto Pietra Pedroso, José Roberto Lambertucci, Manoel Otávio Costa Rocha, Dirceu Bartolomeu Greco, Pedro Raso, Cid Sérgio Ferreira, Davidson Pires de Lima   +6 more
doaj   +3 more sources

Esquistossomose mansoni: tratamento medicamentoso Schistosomiasis mansoni: drug therapeutic

Memorias do Instituto Oswaldo Cruz, 1992
It is the specific treatment of mansoni schistosomiasis that aims to act directed on the parasite, through chemotherapy. Constitutes fundamental indication to the treatment of schistosomiasis active forms, that is, these determined by the presence of ...
Aloisio Sales da Cunha
doaj   +1 more source