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Discovery of Terminal Oxazole-Bearing Natural Products by a Targeted Metabologenomic Approach

open access: yesAngewandte Chemie - International Edition
A targeted metabologenomic method was developed to selectively discover terminal oxazole-bearing natural products from bacteria. For this, genes encoding oxazole cyclase, a key enzyme in terminal oxazole biosynthesis, were chosen as the genomic signature
Dong-Chan Oh, Ki-Bong Oh, Jiyoon Park
exaly   +2 more sources
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Synthesis of functionalised oxazoles and bis-oxazoles 1

Journal of the Chemical Society, Perkin Transactions 1, 1998
A new method for the synthesis of oxazoles, and in particular chiral non-racemic oxazoles derived from amino acids, has been developed. Thus, rhodium(II) catalysed reaction of diazocarbonyl compounds 6 and 11 in the presence of amides 8 and 10 results in regioselective insertion of the carbenoid into the amide N–H bond with formation of the β-carbonyl ...
Mark C. Bagley   +3 more
openaire   +1 more source

Cycloaddition of Fluorinated Oxazoles.

ChemInform, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N. V. Vasil'ev   +5 more
openaire   +1 more source

ChemInform Abstract: Synthesis of Functionalized Oxazoles and Bis‐Oxazoles.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. C. BAGLEY   +3 more
openaire   +1 more source

New oxazole to oxazole recyclization

Chemistry of Heterocyclic Compounds, 2023
Oleh V. Shablykin   +3 more
openaire   +1 more source

Imidazole, oxazole and thiazole alkaloids

Natural Product Reports, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +2 more sources

Direct Arylation of Oxazoles at C2. A Concise Approach to Consecutively Linked Oxazoles

Organic Letters, 2008
The synthesis of bis- and trisoxazoles via direct arylation is discussed. A variety of aryl groups can be installed at the 2-position of 5-aryl and 5-carboxy-substituted oxazoles under mild conditions using palladium catalysis on water. The direct arylation method can be extended to the synthesis of bis- and trisoxazoles if 2-triisopropylsilyl-4 ...
Flegeau, Emmanuel Ferrer   +2 more
openaire   +3 more sources

Monosubstituted Oxazoles. 1. Synthesis of 5-Substituted Oxazoles by Directed Alkylation

The Journal of Organic Chemistry, 1998
A general method is presented for synthesis of 2-(methylthio)-5-substituted oxazoles 2. Deprotonation of the readily available 2-(methylthio)oxazole (1) with n-BuLi occurs smoothly in the presence of TMEDA and regiospecifically at C5. The organometallic 1a added rapidly to aldehydes and other electrophiles to provide 5-substituted-2-(methylthio ...
Cynthia M., Shafer, Tadeusz F., Molinski
openaire   +2 more sources

The rhodium carbenoid route to oxazoles. Synthesis of 4-functionalised oxazoles; Three step preparation of a bis-oxazole

Tetrahedron, 1994
Abstract Oxazole-4-sulfones, -phosphonates, and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound. The effect of the ligand on rhodium was briefly investigated, with rhodium(II) trifluoroacetamide generally proving the most effective catalyst.
Kevin J. Doyle, Christopher J. Moody
openaire   +1 more source

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