Results 21 to 30 of about 2,049,340 (295)
Oxidative stress: oxidants and antioxidants [PDF]
Experimental Physiology, 1997 An imbalance between oxidants and antioxidants in favour of the oxidants, potentially leading to damage, is termed ‘oxidative stress’. Oxidants are formed as a normal product of aerobic metabolism but can be produced at elevated rates under pathophysiological conditions. Antioxidant defense involves several strategies, both enzymatic and non‐enzymatic.
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Paraoxonase Role in Human Neurodegenerative Diseases
Antioxidants, 2020 The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes.
Cadiele Oliana Reichert +2 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Photo-Fenton Degradation of Pentachlorophenol: Competition between Additives and Photolysis
Nanomaterials, 2019 In the present work, the photo-Fenton degradation of pentachlorophenol (PCP, 1 mg/L) has been studied under simulated and natural solar irradiation; moreover, the effect on the process efficiency of urban waste-derived soluble bio-based substances (SBO),
Erika Pia Vergura +5 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
A workplace intervention to reduce alcohol and drug consumption: a nonrandomized single-group study
BMC Public Health, 2018 Background The consumption of alcohol and other drugs causes social and health problems in industrialized societies. Furthermore, alcohol and drug consumption in the workplace is associated with work accidents, absenteeism and low productivity.
Montse Gómez-Recasens +4 more
doaj +1 more source
Foods, 2021 The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (ω-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet.
Bernat Miralles-Pérez +8 more
doaj +1 more source
Oxidative Shielding or Oxidative Stress? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2012 In this review I report evidence that the mainstream field of oxidative damage biology has been running fast in the wrong direction for more than 50 years. Reactive oxygen species (ROS) and chronic oxidative changes in membrane lipids and proteins found in many chronic diseases are not the result of accidental damage.
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source