Results 61 to 70 of about 154,148 (225)

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Associations between the oxidative balance score and constipation: a cross-sectional study of the NHANES, 2005–2010

BMC Public Health
s Objective The oxidative balance score (OBS) reflects the overall burden of oxidative stress in an individual, with a higher OBS indicating greater antioxidant exposure. This study aimed to explore the association between constipation and OBS.
Yuchao Wang, Jiao Li, Wei Sun, Yunbin Tong, Lu Han, Ziying Jiang, Weili Xu, Daqing Sun   +7 more
doaj   +1 more source

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]

, 2018
Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev, A Leibowitz, AA Ferrando, AA Smith, B Lecka-Czernik, C Fasolato, C Harteneck, C Morris, CL Hoppel, D Belelli, D Fietz, E Asmussen, E Chorell, E Pohjanen, G Lac, G Van Hall, GC Bogdanis, GD Lewis, GJ Rietjens, H Budde, H Budde, H Karlic, H Yokoyama, J Henriksson, JB Walker, JH Mitchell, JK Nicholson, JM Peake, JS Fuqua, K Goto, K Sahlin, K Sahlin, K Sato, K Sato, KR Howarth, LS Eriksson, ME Powers, MH Jacob, MH Williams, MJ Ormsbee, ML Circu, ML Goodwin, P Yin, PC Tullson, R Berton, RF Coburn, S Naz, SC Lu, SK Powers, TE Graham, W Dudzinska, YP Pitsiladis   +51 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Maternal Oxidative Balance Score during Pregnancy and Congenital Heart Defects

Nutrients
The relationship between maternal oxidative balance score (OBS) in pregnancy, representing overall oxidative balance status by integrating dietary and lifestyle factors, and congenital heart defects (CHD) remains unclear; therefore, this study attempted to explore their associations among the Chinese population.
Yang, Jiaomei, Du, Qiancheng, Xiao, Ziqi, Guo, Rui, Chang, Qianqian, Li, Yue-Hua   +5 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Associations of oxidative balance score with hyperuricemia and gout among American adults: a population-based study

Frontiers in Endocrinology
ObjectiveThe current study aimed to assess the relationships between oxidative balance score (OBS) and OBS subclasses (dietary and lifestyle OBS) with risks of hyperuricemia (HUA) and gout among American adults.MethodsParticipants in the National Health ...
Kai Wang, Jinyi Wu, Minggang Deng, Minggang Deng, Jiaqi Nie, Fengxi Tao, Qingwen Li, Xin Luo, Fang Xia   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. [PDF]

, 2020
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations.
Anza-Ramirez, Cecilia, Corante, Noemi, DeYoung, Pamela N, Djokic, Matea A, Gaio, Eduardo, Gilbertson, Dillon, Heinrich, Erica C, Macarlupu, Jose L, Malhotra, Atul, Orr, Jeremy E, Powell, Frank L, Simonson, Tatum S, Villafuerte, Francisco C, Vizcardo-Galindo, Gustavo   +13 more
core   +1 more source