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Uncoupling of oxidative phosphorylation
Trends in Biochemical Sciences, 1976Abstract The mechanism of oxidative phosphorylation is one of the most important problems in classical biochemistry, which has defied a solution for over thirty years. Uncouplers are powerful tools in the study of the coupling between oxidation and phosphorylation, and recent studies of photo-affinity labeling and equilibrium binding by uncouplers ...
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An hypothesis for oxidative phosphorylation [PDF]
Presentation d'une hypothese pour la phosphorylation oxidative qui comprend des substances vinyl carbonyl, suivie d'une esquisse d'un systeme cyclique utilisant des quinones, hydroxyquinones, hydroxy-hydroquinones et leurs derives phosphorilates.
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Oxidative phosphorylation revisited
Biotechnology and Bioengineering, 2015ABSTRACTThe fundamentals of oxidative phosphorylation and photophosphorylation are revisited. New experimental data on the involvement of succinate and malate anions respectively in oxidative phosphorylation and photophosphorylation are presented. These new data offer a novel molecular mechanistic explanation for the energy coupling and ATP synthesis ...
Sunil Nath, John Villadsen
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Oxidative phosphorylation in yeast II. An oxidative phosphorylation-deficient mutant
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1968Abstract 1. Mitochondria from the mutant Saccharomyces cerevisiae DH 1 oxidized members of the tricarboxylic acid cycle, d (−)- and l (+)-lactates, ethanol, NADH, and N , N , N ′, N ′-tetramethyl- p -phenylenediamine with P/O ratios found in manometric experiments to be as low as 0.1 to 0.4. The low phosphorylation efficiency was not improved by
L. Kováč, E. Hrušovská
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Mitochondrial Oxidative Phosphorylation
Angewandte Chemie International Edition in English, 1967AbstractMitochondria can form ATP from ADP and inorganic phosphate, the required energy being supplied by respiration. This coupled process, which in sufficiently aerated normal animal cells furnishes the bulk of the cellular ATP, is termed oxidative phosphorylation.
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A Theory of Oxidative Phosphorylation
Nature, 1958EVIDENCE has been put forward that naphthoquinone derivatives take part in the phosphorylation of adenosine diphosphate to adenosine triphosphate by animal tissues1, chloroplasts2 and bacteria3. A similar role in phosphorylation by animal tissues has been proposed for α-tocopherylquinone4. It is therefore possible to formulate an earlier suggestion5 in
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Oxidative Phosphorylation Disease Diagnosis [PDF]
ABSTRACT: Although the mtDNA encodes only 13 polypeptide subunits of the OXPHOS enzymes, approximately 1,000 proteins are estimated to be necessary for proper OXPHOS function. Over the past 10 years a wide variety of adult and pediatric OXPHOS diseases were found to be caused by or associated with mitochondrial DNA (mtDNA) mutations and nuclear DNA ...
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The genetics and pathology of oxidative phosphorylation
Nature Reviews Genetics, 2001The mitochondrial oxidative phosphorylation (OXPHOS) system is the final biochemical pathway in the production of ATP. The OXPHOS system consists of five multiprotein complexes, the individual subunits of which are encoded either by the mitochondrial or by the nuclear genome.
Smeitink, J.A.M.+2 more
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Non-phosphorylated intermediates in oxidative phosphorylation
Biochimica et Biophysica Acta, 1963Abstract 1. 1. This paper is concerned with the study of the formation of non-phosphorylated intermediates in digitonin particles prepared from rat-liver mitochondria. 2. 2. Digitonin particles were preincubated with either β-hydroxybutyrate, sucinate or ferrocytochrome c for a short time at 20°.
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Evidence of a phosphorylated intermediate in mitochondrial oxidative phosphorylation
Biochemical and Biophysical Research Communications, 1970Abstract The effects of aurovertin and oligomycin on the rates of oxidative phosphorylation and arsenate-stimulated respiration have been studied over a wide range of concentrations. It has been found that both arsenate and phosphate can react with an energy-rich intermediate of oxidative phosphorylation even when reaction with ADP is prevented by ...
Jui H. Wang, Richard L. Cross
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