Results 141 to 150 of about 309,295 (244)

SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice. [PDF]

open access: yesJ Mol Cell Cardiol Plus
Chambers JM   +8 more
europepmc   +1 more source

MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang   +10 more
wiley   +1 more source

Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation. [PDF]

open access: yesJ Bone Miner Res
Qiu H   +12 more
europepmc   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang   +6 more
wiley   +1 more source

Normal Oxidative Phosphorylation in Mitochondria from the Failing Heart

open access: bronze, 1967
Burton E. Sobel   +4 more
openalex   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

open access: yesAdvanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding   +14 more
wiley   +1 more source

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