Finding Acceptable Parameter Regions of Stochastic Hill functions for Multisite Phosphorylation Mechanism [PDF]
The Journal of Chemical Physics 152.12 (2020): 124108, 2020 Multisite phosphorylation plays an important role in regulating switchlike protein activity and has been used widely in mathematical models. With the development of new experimental techniques and more molecular data, molecular phosphorylation processes emerge in many systems with increasing complexity and sizes.
arxiv +1 more source
Oxidative phosphorylation in bone cells
Bone Reports, 2023 The role of energy metabolism in bone cells is an active field of investigation. Bone cells are metabolically very active and require high levels of energy in the form of adenosine triphosphate (ATP) to support their function. ATP is generated in the cytosol via glycolysis coupled with lactic acid fermentation and in the mitochondria via oxidative ...
Sabini E. +4 more
openaire +4 more sources
Bond Graph Modelling of Chemiosmotic Biomolecular Energy Transduction [PDF]
IEEE Transactions on NanoBioscience, 16(3):177-188, April 2017, 2016 Engineering systems modelling and analysis based on the bond graph approach has been applied to biomolecular systems. In this context, the notion of a Faraday-equivalent chemical potential is introduced which allows chemical potential to be expressed in an analogous manner to electrical volts thus allowing engineering intuition to be applied to ...
arxiv +1 more source
In distributive phosphorylation catalytic constants enable non-trivial dynamics [PDF]
arXiv, 2023 Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphorylated first) or cyclic (where the site phosphorylated first is dephosphorylated first).
arxiv
Murburn concept: A facile explanation for oxygen-centered cellular respiration [PDF]
Biomedical Reviews, 2017, 28, 35-52, 2017 Via a concomitant communication (the first part of my work), I have conclusively debunked the prevailing explanations for mitochondrial oxidative phosphorylation and established the need for a novel rationale to account for the reaction paradigm. Towards the same, murburn concept is hereby floated as a viable explanation (in the second part of my work).
arxiv +1 more source
The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway [PDF]
Biophys. J. 107, 2425--2435, 2014, 2014 Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation site allows for proofreading, especially when phosphorylation is distributive rather than processive.
arxiv +1 more source
Self-Organization and Fractality in a Metabolic Process of the Krebs Cycle [PDF]
Ukr.Biochem.J. 2013; Volume 85, Issue 5, Sep-Oct, pp. 191-200, 2017 With the help of a mathematical model, the metabolic process of the Krebs cycle is studied. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its dynamics are determined.
arxiv +1 more source
A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]
arXiv, 2020 Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv
Targeting cytochrome C oxidase in mitochondria with Pt(II)-porphyrins for Photodynamic Therapy [PDF]
, 2010 Mitochondria are the power house of living cells, where the synthesis of the chemical "energy currency" adenosine triphosphate (ATP) occurs. Oxidative phosphorylation by a series of membrane protein complexes I to IV, that is, the electron transport chain, is the source of the electrochemical potential difference or proton motive force (PMF) of protons
arxiv +1 more source
Nonequilibrium calcium dynamics optimizes the energetic efficiency of mitochondrial metabolism [PDF]
arXiv, 2023 Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of specific cellular processes remains a largely open problem.
arxiv