Results 11 to 20 of about 3,315,390 (285)

Mitochondrial Oxidative Phosphorylation in Viral Infections

Viruses, 2023
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling ...
Neeraja Purandare, Esha Ghosalkar, Lawrence I. Grossman, Siddhesh Aras   +3 more
doaj   +1 more source

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. [PDF]

PLoS ONE, 2011
Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear.
Michael P Siegel, Shane E Kruse, Gary Knowels, Adam Salmon, Richard Beyer, Hui Xie, Holly Van Remmen, Steven R Smith, David J Marcinek   +8 more
doaj   +1 more source

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Nature Immunology, 2020
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined.
S. Vardhana, Madeline A. Hwee, Mirela Berisa, Daniel K. Wells, K. Yost, B. King, Melody Smith, Pamela S. Herrera, Howard Y. Chang, Ansuman T. Satpathy, M. V. D. van den Brink, J. Cross, C. Thompson   +12 more
semanticscholar   +1 more source

mPTP opening differently affects electron transport chain and oxidative phosphorylation at succinate and NAD-dependent substrates oxidation in permeabilized rat hepatocytes [PDF]

The Ukrainian Biochemical Journal, 2020
Mitochondrial Ca2+ overload may trigger the opening of mitochondrial permeability transition pore (mPTP) and its prolonged activation leads to cell death. ATP synthase is considered as a possible molecular component of the pore. The aim of this study was
H. M. Mazur , V. M. Merlavsky , B. O. Manko, V. V. Manko   +3 more
doaj   +1 more source

Remodelling of the Mitochondrial Bioenergetic Pathways in Human Cultured Fibroblasts with Carbohydrates

Biology, 2023
Mitochondrial oxidative phosphorylation defects underlie many neurological and neuromuscular diseases. Patients’ primary dermal fibroblasts are one of the most commonly used in vitro models to study mitochondrial pathologies. However, fibroblasts tend to
Margherita Protasoni, Jan-Willem Taanman
doaj   +1 more source

Down syndrome is an oxidative phosphorylation disorder

Redox Biology, 2021
Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression
M. Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Eldris Iglesias, Irene Jiménez-Salvador, Julio Montoya, Carmen Martínez-Cué, Eduardo Ruiz-Pesini   +7 more
doaj   +1 more source

Oxidative Phosphorylation-Related Signature Participates in Cancer Development, and PTPRG Overexpression Suppresses the Cancer Progression in Clear Cell Renal Cell Carcinoma

Journal of Immunology Research, 2022
Clear cell renal cell carcinoma (ccRCC) was a common cancer type diagnosed with frequent metastases, harboring an unfavorable therapeutic response, and results in a poor prognosis.
Liang Huang, Yu Xie, Weiqing Han, Shusuan Jiang, Lingfeng Zeng   +4 more
doaj   +1 more source

Low level of mancozeb exposure affects ovary in mice

Ecotoxicology and Environmental Safety, 2022
Mancozeb (MCZ) is widely used as a protective fungicide. This study aimed to explore the effects of low level MCZ exposure on ovary in mice. Twenty Kunming mice were randomly divided into control and MCZ groups (10 mice each).
Jialu Bao, Yan Zhang, Ran Wen, Linchao Zhang, Xiaodan Wang   +4 more
doaj   +1 more source

Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance We demonstrate that Akt phosphorylation of Mdm2 protein at Ser183 inhibits p53-mediated senescence and promotes ROS-induced tumorigenesis. Thus, different effector kinases can modify Mdm2 and selectively regulate the p53-mediated response to
Loretah Chibaya, Baktiar O Karim, Hong Zhang, S. Jones   +3 more
semanticscholar   +1 more source

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

Journal of Medicinal Chemistry, 2020
Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive. Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to chemotherapy and targeted therapies.
Yibin Xu, D. Xue, A. Bankhead, N. Neamati   +3 more
semanticscholar   +1 more source