Results 11 to 20 of about 3,781,647 (383)

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Redox Biology, 2020
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation.
Deirdre Nolfi-Donegan, Andrea Braganza, Sruti Shiva   +2 more
doaj   +2 more sources

Oxidative Phosphorylation Impairment by DDT and DDE

Frontiers in Endocrinology, 2019
There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity ...
Sarah E. Elmore, Michele A. La Merrill
doaj   +2 more sources

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

Nature Network Boston, 2023
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into ...
T. Yap, N. Daver, Mikhila Mahendra, Jixiang Zhang, C. Kamiya-Matsuoka, F. Meric-Bernstam, H. Kantarjian, F. Ravandi, Meghan Collins, M. D. Francesco, E. Dumbrava, S. Fu, Sisi Gao, J. Gay, S. Gera, Jingchao Han, David S. Hong, E. Jabbour, Z. Ju, D. Karp, A. Lodi, J. Molina, Natalia Baran, A. Naing, M. Ohanian, S. Pant, N. Pemmaraju, P. Bose, S. Piha-Paul, J. Rodón, C. Salguero, K. Sasaki, A. Singh, V. Subbiah, A. Tsimberidou, Quanyu Xu, M. Yilmaz, Qi Zhang, Yuan Li, C. Bristow, M. Bhattacharjee, S. Tiziani, T. Heffernan, C. Vellano, Philip Jones, C. Heijnen, A. Kavelaars, J. Marszalek, M. Konopleva   +48 more
semanticscholar   +1 more source

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Communications Biology, 2022
New research shows that disease-associated microglia in neurodegenerative brains present features of elevated phagocytosis, lysosomal functions, and lipid metabolism, which benefit brain repair.
Shanshan Song, Lauren Yu, Md Nabiul Hasan, S. Paruchuri, S. Mullett, M. Sullivan, Victoria M. Fiesler, C. Young, D. Stolz, S. Wendell, Dandan Sun   +10 more
semanticscholar   +1 more source

The Effect of Oxidative Phosphorylation on Cancer Drug Resistance

Cancers, 2022
Simple Summary Drug therapy is an important treatment for cancer patients; however, drug resistance severely affects the survival time and quality of life of cancer patients.
Ziyi Zhao, Yong Mei, Ziyang Wang, Wei-ling He   +3 more
semanticscholar   +1 more source

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. [PDF]

PLoS ONE, 2011
Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear.
Michael P Siegel, Shane E Kruse, Gary Knowels, Adam Salmon, Richard Beyer, Hui Xie, Holly Van Remmen, Steven R Smith, David J Marcinek   +8 more
doaj   +1 more source

mPTP opening differently affects electron transport chain and oxidative phosphorylation at succinate and NAD-dependent substrates oxidation in permeabilized rat hepatocytes [PDF]

The Ukrainian Biochemical Journal, 2020
Mitochondrial Ca2+ overload may trigger the opening of mitochondrial permeability transition pore (mPTP) and its prolonged activation leads to cell death. ATP synthase is considered as a possible molecular component of the pore. The aim of this study was
H. M. Mazur , V. M. Merlavsky , B. O. Manko, V. V. Manko   +3 more
doaj   +1 more source

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Nature Immunology, 2020
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined.
S. Vardhana, Madeline A. Hwee, Mirela Berisa, Daniel K. Wells, K. Yost, B. King, Melody Smith, Pamela S. Herrera, Howard Y. Chang, Ansuman T. Satpathy, M. V. D. van den Brink, J. Cross, C. Thompson   +12 more
semanticscholar   +1 more source

Remodelling of the Mitochondrial Bioenergetic Pathways in Human Cultured Fibroblasts with Carbohydrates

Biology, 2023
Mitochondrial oxidative phosphorylation defects underlie many neurological and neuromuscular diseases. Patients’ primary dermal fibroblasts are one of the most commonly used in vitro models to study mitochondrial pathologies. However, fibroblasts tend to
Margherita Protasoni, Jan-Willem Taanman
doaj   +1 more source

Down syndrome is an oxidative phosphorylation disorder

Redox Biology, 2021
Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression
M. Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Eldris Iglesias, Irene Jiménez-Salvador, Julio Montoya, Carmen Martínez-Cué, Eduardo Ruiz-Pesini   +7 more
doaj   +1 more source