Results 41 to 50 of about 1,214,681 (294)

Time-resolved mitochondrial screen identifies regulatory components of oxidative metabolism

EMBO Reports
Defects in mitochondrial oxidative metabolism underlie many genetic disorders with limited treatment options. The incomplete annotation of mitochondrial proteins highlights the need for a comprehensive gene inventory, particularly for Oxidative ...
Marcos Zamora-Dorta, Sara Laine-Menéndez, David Abia, Pilar González-García, Luis C López, Paula Fernández-Montes, Enrique Calvo, Jesús Vázquez, José Antonio Enríquez, Eduardo Balsa   +9 more
doaj   +1 more source

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Journal of Aging Research, 2012
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue.
Claus Desler, Thomas Lau Hansen, Jane Bruun Frederiksen, Maiken Lise Marcker, Keshav K. Singh, Lene Juel Rasmussen   +5 more
doaj   +1 more source

DEGs related to oxidative phosphorylation.

, 2019
DEGs related to oxidative phosphorylation.
Zhigang Yang (547420), Yongxu Cheng (508767), Junyu Zhou (1548346), Long Zhang (315279), Banghong Wei (4284697), Xiaomin Zhen (6195482)   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Construction and Validation of an Oxidative Phosphorylation Signature in High-Grade Glioma and Potential Inhibitors Screening

Analytical Cellular Pathology
Glioma is a devastating type of brain tumor with high morbidity and mortality rates. Despite current treatment options, the prognosis for glioma patients remains poor.
Hanwen Lu, Wenpeng Zhao, Bingchang Zhang, Yuanyuan Xie, Jiawei He, Huiying Yang, Zhanxiang Wang   +6 more
doaj   +1 more source

Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells. [PDF]

PLoS ONE, 2016
Recently, targeting cancer stem cells (CSCs) metabolism is becoming a promising therapeutic approach to improve cancer treatment outcomes. However, knowledge of the metabolic state of CSCs in small cell lung cancer is still lacking.
Cuicui Gao, Yao Shen, Fang Jin, Yajing Miao, Xiaofei Qiu   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Oxidative phosphorylation pathway (LL vs. CC).

, 2019
Oxidative phosphorylation pathway (LL vs. CC).
Yang-yang Pang (6157208), Gen-yong Huang (6208661), Min-jie Xu (4976480), Xiao-zhen Yang (6157220), Cong Zhang (582922), Yong-xu Cheng (6157217)   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Supplementary Data from PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer

, 2022
Supplementary Data from PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian ...
MariaRosa Bani (14955928), Paola Ostano (14844743), Massimo Russo (14955922), Roberta Pastorelli (6050858), Raffaella Giavazzi (64690), Edoardo Arrigoni (14955925), Giovanna Chiorino (14942404), Catarina Moreira-Barbosa (5907095), Joseph R. Marszalek (9045521), Monica Salio (5428205), Alessia Anastasia (14955916), Nicolò Panini (11420916), Ferdinando Chiaradonna (268214), Fabio Fiordaliso (14955919), Alessandra Decio (14844834), Giulio Draetta (1586296), Laura Formenti (14844837), Christopher P. Vellano (2233237), Carmen Ghilardi (14844855), Monica Lupi (14955913), Laura Brunelli (6050861)   +20 more
core   +2 more sources