Results 61 to 70 of about 1,214,681 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Increased hepatic fatty acids uptake and oxidation by LRPPRC-driven oxidative phosphorylation reduces blood lipid levels

Frontiers in Physiology, 2016
Hyperlipidemia is one of the major risk factors of atherosclerosis and other cardiovascular diseases. This study aimed to investigate the impact of leucine rich pentatricopeptide repeat containing protein (LRPPRC)-driven hepatic oxidative phoshorylation ...
Ping Zhou, Chi Wei, Xin-yan Wang, Jun-lin Li, Wei He, Mei-zhen Gong, Di Wang, Shi Lei   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Chronic ethanol ingestion increases efficiency of oxidative phosphorylation in rat liver mitochondria.

, 2000
International audienceThe efficiency of oxidative phosphorylation was compared between rats chronically fed with ethanol and controls. (i) Results showed that the liver mitochondria state 4 respiratory rate was strongly inhibited, while the corresponding
Rigoulet, Michel, A Devin, Filippi, Céline, Roulet, Michel, Piquet, Marie-Astrid, Fontaine, Eric, M., Fontaine, Eric,, E Fontaine, M Roulet, Devin, Anne, B Sibille, X.M Leverve, V Nogueira, Leverve, Xavier, M, M Rigoulet, Leverve, Xavier,, Nogueira, Véronique, M.A Piquet, Sibille, Brigitte, C Filippi, Leverve, X. M., Sibille, B., Roulet, M., Filippi, C., Devin, A., Fontaine, E., Rigoulet, M., Piquet, M. A., Nogueira, V.   +28 more
core   +2 more sources

Oxidative Phosphorylation Impairment by DDT and DDE

Frontiers in Endocrinology, 2019
There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity ...
Sarah E. Elmore, Michele A. La Merrill
doaj   +1 more source

Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Metabolites, 2022
Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms.
Hélène Lemieux, Pierre U. Blier
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis [PDF]

, 2005
Several kinases phosphorylate vimentin, the most common intermediate filament protein, in mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the cleavage furrow-specific vimentin phosphorylation.
Erich A. Nigg, Andreas Uldschmid, Hanisch, Anja, Uldschmid, Andreas, Takashi Oguri, Takai, Yasushi, Tomoya Yamaguchi, Yasushi Takai, Masaki Inagaki, Goto, Hidemasa, Tomoya Yokoyama, Anja Hanisch, Hidemasa Goto, Silljé, Herman, Herman Silljé, Oguri, Takashi, Yamaguchi, Tomoya, Nigg, Erich A., Inagaki, Masaki, Yokoyama, Tomoya   +19 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source