Results 51 to 60 of about 1,214,681 (294)

Multi-Bioinformatics Approach Reveals COX5B-Mediated Modulation of Oxidative Phosphorylation and ROS Levels by Water and Ethanol Extracts of Schisandrae Fructus in SW1783 Cells

Antioxidants
Schisandrae Fructus is a traditional medicinal herb used to suppress hyperactivity and exhibits a wide range of therapeutic effects and few side effects; however, the molecular mechanism of action engaged by the multiple compounds found within ...
Musun Park, No Soo Kim, Jin-Mu Yi, Seongwon Cha   +3 more
doaj   +1 more source

Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

Scientific Reports, 2017
Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather than oxidative phosphorylation even in the presence of oxygen. However, recent studies have shown
Sajad Dar, Jasdeep Chhina, Ismail Mert, Dhananjay Chitale, Thomas Buekers, Hareena Kaur, Shailendra Giri, Adnan Munkarah, Ramandeep Rattan   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Oxidative Phosphorylation as a Predictive Biomarker of Oxaliplatin Response in Colorectal Cancer

Biomolecules
Oxaliplatin is successfully used on advanced colorectal cancer to eradicate micro-metastasis, whereas its benefits in the early stages of colorectal cancer remains controversial since approximately 30% of patients experience unexpected relapses.
Toni Martinez-Bernabe, Daniel G. Pons, Jordi Oliver, Jorge Sastre-Serra   +3 more
doaj   +1 more source

Accurate determination of the oxidative phosphorylation affinity for ADP in isolated mitochondria.

PLoS ONE, 2011
BackgroundMitochondrial dysfunctions appear strongly implicated in a wide range of pathologies. Therefore, there is a growing need in the determination of the normal and pathological integrated response of oxidative phosphorylation to cellular ATP demand.
Gilles Gouspillou, Richard Rouland, Guillaume Calmettes, Véronique Deschodt-Arsac, Jean-Michel Franconi, Isabelle Bourdel-Marchasson, Philippe Diolez   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Oxidative Phosphorylation System in Mammalian Mitochondria

, 2011
The chapter provides a review of the state of art of the oxidative phosphorylation system in mammalian mitochondria. The sections of the paper deal with: (i) the respiratory chain as a whole: redox centers of the chain and protonic coupling in ...
Domenico De Rasmo, Giuseppe Capitanio, Antonio Gaballo, Sergio Papa, Pietro Luca Martino, Anna Signorile, Vittoria Petruzzella, Petruzzella V., Martino P. L., Papa S., De Rasmo D., Capitanio G., Gaballo A., Signorile A.   +13 more
core   +1 more source

PhosPhAt : the Arabidopsis thaliana phosphorylation site database : an update [PDF]

, 2009
The PhosPhAt database of Arabidopsis phosphorylation sites was initially launched in August 2007. Since then, along with 10-fold increase in database entries, functionality of PhosPhAt (phosphat.mpimp-golm.mpg.de) has been considerably upgraded and re ...
Nagel, Alexander, Jones, A., Kersten, B, Durek, P, Kersten, B., Heazlewood, JL, Heazlewood, J. L., Heazlewood, J., MacLean, D, Nagel, A, Schulze, W. X., Nagel, A., Schmidt, R, Jones, Alexandra M., Schulze, W., Kersten, Birgit, Jones, A, Durek, P., Schmidt, R., MacLean, D., Schulze, WX, MacLean, Daniel, Schmidt, Robert, Jones, Alexandra, Durek, Pawel, Schulze, Waltraud X., Nagel, Axel, Heazlewood, Joshua L.   +27 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oxidative phosphorylation provides stress resistance in non-proliferating cells

, 2021
Mitochondrial oxidative phosphorylation (OXPHOS) generates ATP, but also has other important roles that are ATP-independent. In proliferating cells OXPHOS is required for pyrimidine synthesis, but in non-proliferating cells its ATP-unrelated functions ...
Rohlena, Jakub, Rohlenova, Katerina, Magalhaes Novais, Silvia, Neuzil, Jiri, Blecha, Jan, Katerina Rohlenova, Silvia Magalhaes Novais, Jan Blecha, Jakub Rohlena, Jiri Neuzil   +9 more
core   +1 more source