Results 21 to 30 of about 75,015 (242)

Advances on glycolysis-oriented metabolic reprogramming and targeted therapeutics in pneumoconiosis

环境与职业医学
Pneumoconiosis is a chronic interstitial lung disease caused by occupational exposure to mineral dust, characterized by persistent inflammation and progressive pulmonary fibrosis. Effective therapeutic options, however, remain limited. Recent multi-omics
Siqi YANG, Ting LIU, Yiwei SHI
doaj   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression

Scientific Reports
Hepatocellular carcinoma (HCC) represents a significant global health challenge due to its molecular heterogeneity and the immunosuppressive nature of its tumor microenvironment (TME).
Yimin Nong, Xiaolong Chen, Baoxin Zhang, Zhenyin Lin, Wuriniletu, Chengyou Du, Qiang Liu   +6 more
doaj   +1 more source

Hydrated proton complexes supplementation for tumor microenvironment reprogramming: a bioenergetic strategy targeting the Warburg effect and mitochondrial dysfunction

Frontiers in Oncology
BackgroundThe tumor microenvironment (TME) is characterized by a reversed pH gradient—acidic extracellular and alkaline intracellular conditions—arising from mitochondrial dysfunction, metabolic reprogramming, and dysregulated proton transport.
Alfred Lee Edgar, Luis Felipe Dias Lopes, Eduarda Grando Lopes, Izabella Danezi Felin, Carlos Roberto Felin, João Francisco Pollo Gaspary   +5 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

JOR Spine
Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain. Abnormal mechanical stress causes intracellular Ca2+ overload by activating the Piezo‐type
Yunbo Yang, Haoming Li, Junhui Zuo, Fei Lei   +3 more
doaj   +1 more source

Metformin as a Therapeutic Target in Endometrial Cancers. [PDF]

, 2018
Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of ...
Johnson, Jennifer, Kim, Christine H., Lee, Teresa, Martinez-Outshoorn, Ubaldo E., Richard, Scott D., Rosenblum, Norman G., Schilder, Russell J.   +6 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source