Results 71 to 80 of about 1,592,981 (302)

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core  

Phenolic content of Hypodaphnis Zenkeri and its antioxidant effects against fenton reactions’ mediated oxidative injuries on liver homogenate [PDF]

, 2014
Under oxidative stress conditions, endogenous antioxidant defenses are unable to completely inactivate the free radicals generated by an excessive production of reactive oxygen species (ROS).
Biapa, Bopanna, Choumessi, Cvjetko, Djacbou, Dongmo, Etoundi, Garratt, Israhad, Maestri, Misra, Molyneux, Panda, Singleton, Titanji   +14 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MANTLE TERRANES OF THE SIBERIAN CRATON: THEIR INTERACTION WITH PLUME MELTS BASED ON THERMOBAROMETRY AND GEOCHEMISTRY OF MANTLE XENOCRYSTS

Геодинамика и тектонофизика, 2019
We have studied variations in the structure and composition of minerals from the pipes of the Yakutian kimberlite province (YKP) in different mantle terranes of the Siberian craton.
I. V. Ashchepkov, A. S. Ivanov, S. I. Kostrovitsky, M. A. Vavilov, S. A. Babushkina, N. V. Vladykin, N. S. Tychkov, N. S. Medvedev   +7 more
doaj   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Novel biosensors reveal a shift in the redox paradigm from oxidative to reductive stress in heart disease [PDF]

, 2016
No abstract ...
Anagnostopoulou, Aikaterini, De Lucca Camargo, Livia, Montezano, Augusto, Touyz, Rhian   +3 more
core   +1 more source

Myeloperoxidase Potentiates Nitric Oxide-mediated Nitrosation [PDF]

Journal of Biological Chemistry, 2005
Nitrosation is an important reaction elicited by nitric oxide (NO). To better understand how nitrosation occurs in biological systems, we assessed the effect of myeloperoxidase (MPO), a mediator of inflammation, on nitrosation observed during NO autoxidation.
Vijaya M, Lakshmi, William M, Nauseef, Terry V, Zenser   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source