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Microcirculation and oxidative stress

Free Radical Research, 2007
The microcirculation is a complex and integrated system, transporting oxygen and nutrients to the cells. The key component of this system is the endothelium, contributing to the local balance between pro and anti-inflammatory mediators, hemostatic balance, as well as vascular permeability and cell proliferation.
CRIMI E, IGNARRO LJ, NAPOLI, Claudio
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Oxidative Stress and the Ovary

Journal of the Society for Gynecologic Investigation, 2001
Superoxide (O(2)(-)), hydrogen peroxide (H(2)O(2)), and lipid peroxides are generated in luteal tissue during natural and prostaglandin-induced regression in the rat, and this response is associated with reversible depletion of ascorbic acid. Reactive oxygen species immediately uncouple the luteinizing hormone receptor from adenylate cyclase and ...
H R, Behrman   +3 more
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Oxidant signals and oxidative stress

Current Opinion in Cell Biology, 2003
Although oxidants clearly possess the capacity to behave in a random and destructive fashion, growing evidence suggests that in many instances the production of reactive oxygen species is tightly regulated and their downstream targets exquisitely specific.
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Oxidative stress in uremia

Current Opinion in Nephrology and Hypertension, 2003
Oxidative stress has been described as 'a disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. In uremic patients, an increase in oxidative stress may occur because of the loss of residual renal function, and may be exacerbated by dialysis.
Jonathan, Himmelfarb, Raymond M, Hakim
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Oxidative Stress and Infection

2012
Male accessory gland infections (MAGI) are included among the conventional diagnostic categories recognized to cause male infertility. They constitute a clinical model of oxidative stress for a number of considerations: (a) some uropathogens or etiological agents of sexually transmitted diseases (Chlamydia trachomatis, Ureaplasma urealyticum) by ...
VICARI, Enzo Saretto   +2 more
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Biochemistry of oxidative stress

European Journal of Cancer and Clinical Oncology, 1986
AbstractAs a normal attribute of aerobic life, structural damage to organic compounds of a wide variety (DNA, proteins, carbohydrates and lipids) may occur as a consequence of oxidative reactions. Oxidative damage inflicted by reactive oxygen species has been called “oxidative stress”.
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Oxidative Stress and Neurodegeneration

Annals of the New York Academy of Sciences, 2005
Abstract: Oxidative stress is a well‐studied early response in chronic neurodegenerative diseases, including Alzheimer's disease, where neuronal loss can exceed 90% in the vulnerable neuronal population. Oxidative stress affects all classes of macromolecules (sugar, lipids, proteins, and DNA), leading inevitably to neuronal dysfunction.
Paula I, Moreira   +5 more
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Oxidant stress and atherosclerosis

Current Opinion in Pharmacology, 2004
Overproduction of reactive oxygen species or increased oxidative stress is considered a major mechanism involved in the pathogenesis of endothelial dysfunction, the initiation and progression of atherosclerosis and its adverse events. Evidence supports the importance of nitric oxide derived from endothelial nitric oxide synthase as a vasoprotective ...
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Oxidative Stress in Hemodialysis

2008
Patients with advanced chronic kidney disease are at a greatly increased cardiovascular risk that cannot be explained entirely by traditional cardiovascular risk factors. An increase in oxidative stress is proposed as a non-traditional cardiovascular risk factor in this patient population.
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Biochemistry of oxidative stress

Biochemical Society Transactions, 2007
The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.
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