Results 181 to 190 of about 2,027,258 (333)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Antistaphylococcal activity of 3D-printed titanium implants with magnesium‑containing multicomponent coating

Гений oртопедии
Introduction Titanium has been successfully employed as artificial implants in orthopedic surgery for decades. Surgical intervention, specifically the implantation of medical devices, carries a risk of implant-associated infection (IAI), the causative ...
Ekaterina M. Gordina, Svetlana A. Bozhkova, Dmitry V. Labutin, Marina V. Bogma, Alexander A. Eruzin   +4 more
doaj   +1 more source

The Modification of Nitrogen to Modulate Perovskite for the Application of p-Type Transparent Conductive Oxides. [PDF]

Molecules
Liang Y, Li K, Chen H, Wang Y, Zheng S, Bai L.   +5 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Nanostructured Oxides Obtained by Anodizing Aluminum Intermetallic Alloys. [PDF]

Materials (Basel)
Chilimoniuk-Szwarc P, Dobroń P, Stępniowski WJ.   +2 more
europepmc   +1 more source

Transformation of β-Lactam Antibacterial Agents during Aqueous Ozonation: Reaction Pathways and Quantitative Bioassay of Biologically-Active Oxidation Products

, 2010
Michael C. Dodd, Daniel Rentsch, Heinz Singer, Hans‐Peter E. Kohler, Urs von Gunten   +4 more
openalex   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

A generalized approach for enhancing contact-electro-catalysis of oxides in a broad temperature range by fluorination. [PDF]

Nat Commun
Wang Z, Dong X, Wu N, Feng Y, Yang X, Li H, Yang Z, Tang W, Wang ZL.   +8 more
europepmc   +1 more source

CO Oxidation Mechanisms on CoO_x-Pt Thin Films

, 2020
Heath Kersell, Zahra Hooshmand, George Yan, Duy Le, Huy Nguyen, Baran Eren, Chenghao Wu, Iradwikanari Waluyo, Adrian Hunt, Slavomír Nemšák, Gábor A. Somorjai, Talat S. Rahman, Philippe Sautet, Miquel Salmerón   +13 more
openalex   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source