Results 61 to 70 of about 375,694 (300)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Study on the piezoresistivity of Cr-doped V2O3 thin film for MEMS sensor applications

Microsystems & Nanoengineering
Cr-doped V2O3 thin film shows a huge resistivity change with controlled epitaxial strain at room temperature as a result of a gradual Mott metal-insulator phase transition with strain.
Michiel Gidts, Wei-Fan Hsu, Maria Recaman Payo, Shaswat Kushwaha, Frederik Ceyssens, Dominiek Reynaerts, Jean-Pierre Locquet, Michael Kraft, Chen Wang   +8 more
doaj   +1 more source

Characterisation of Taal Volcanic Ash as a Potential Raw Material for the Construction Industry [PDF]

Kemija u Industriji
The phreatomagmatic eruption of Taal Volcano in Batangas, Philippines, in January 2020 resulted in a massive ash plume covering a large portion of nearby provinces, including Metro Manila.
Michael S. Lagmay, Admer Rey C. Dablio, Elyson Keith P. Encarnacion, Ruth L. Damian, Emma D. Tayag, Liwayway M. Piquero, Noel Angelo P. Kalacas, John Joshua L. Sergote, Mark Anthony M. Principe, Joel B. Jane   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Possibilities for carbon sequestration in Irish forests. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2000
Ireland has a rapidly expanding forest estate which covers some 9/ of the land area. It is government policy to increase this to 17/ by the year 2030. Preliminary studies suggest that forestry activities have the potential to contribute significantly to ...
Byrne K.A., Perks M.
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Copper catalyzed one-pot synthesis of beta-ketophosphine oxides from ketones and H-phosphine oxides

, 2017
A facile and efficient copper catalyzed one-pot method has been developed for the formation of beta-ketophosphine oxides from ketones and H-phosphine oxides under air at room temperature, in which vinylhydrazinedicarboxylate was formed as the key ...
Ji, JX, Wei, W (reprint author), Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China., Yi, D, Du, FT (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Yang, L, Zhang, ZJ, Chen, SY, Liang, W, Du, FT, Wei, W, Fu, Q   +10 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source