Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL. [PDF]
PLoS ONE, 2016 Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with type 2 diabetes. Here, we investigated whether the endoplasmic reticulum (ER)
Valérie Plaisance +14 more
doaj +5 more sources
Oxidized LDL bind to nonproteoglycan components of smooth muscle extracellular matrices
Journal of Lipid Research, 2001 Arterial wall lipid retention is believed to be due primarily to ionic interactions between lipoproteins and proteoglycans. Thus, oxidized low density lipoproteins (LDL), with decreased positive charge relative to native LDL, should have decreased ...
Mary Y. Chang +3 more
doaj +2 more sources
Oxidized LDL is stable in human serum under extended thawed-state conditions ranging from −20 °C to room temperature [PDF]
Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023 Introduction: Oxidized LDL (oxLDL) is formed by the spontaneous reaction between aldehyde byproducts of lipid peroxidation and lysine residues of apolipoprotein B within LDL.
Nilojan Jehanathan +5 more
doaj +2 more sources
The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes. [PDF]
Chronic Dis Transl Med, 2023 Rabizadeh S +8 more
europepmc +3 more sources
Orticumab: the potential to harness oxidized LDL to reduce coronary inflammation with plaque-targeted therapy. [PDF]
Curr Opin LipidolFarina CJ, Lu W, Nilsson J.
europepmc +2 more sources
Frontiers in Veterinary Science, 2015 Oxidized low-density lipoprotein (LDL) is thought to play an important role in the inflammatory response associated with human obesity. The purpose of this preliminary study was to determine oxidized LDL concentrations in healthy dogs and cats, and to ...
Nobuko eMori, Toshiro eArai
doaj +1 more source
Involvement of Low‐Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Recently, we and others have reported a causal role for oxidized lipids in the pathogenesis of pulmonary hypertension (PH). However, the role of low‐density lipoprotein receptor (LDL‐R) in PH is not known.
Soban Umar +15 more
doaj +1 more source
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H. +11 more
core +1 more source