Results 41 to 50 of about 89,126 (347)

Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice

Journal of Lipid Research, 2004
This study tests the hypothesis that autoantibodies to oxidation epitopes on oxidized LDL (OxLDL) promote the clearance of OxLDL from the plasma. Human LDL (hLDL) was injected into immune-competent apolipoprotein E-deficient (apoE−/−) mice and immune ...
Catherine A. Reardon, Elizabeth R. Miller, Lydia Blachowicz, John Lukens, Christoph J. Binder, Joseph L. Witztum, Godfrey S. Getz   +6 more
doaj   +1 more source

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

Journal of Biological Chemistry, 1989
The formation of cholesterol-loaded macrophage foam cells in arterial tissue may occur by the uptake of modified lipoproteins via the scavenger receptor pathway. The macrophage scavenger receptor, also called the acetylated low density lipoprotein (Ac-LDL) receptor, has been reported to recognize Ac-LDL as well as oxidized LDL species such as ...
C P, Sparrow, S, Parthasarathy, D, Steinberg   +2 more
openaire   +2 more sources

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL, Moorhead, JF, Powis, SH, Ruan, XZ, Tao, JL, Varghese, Z, Wheeler, DC   +6 more
core   +1 more source

The oxidative modification of low-density lipoproteins by macrophages [PDF]

Biochemical Journal, 1990
1. Mouse resident peritoneal macrophages in culture modified human 125I-labelled low-density lipoprotein (LDL) to a form that other macrophages took up about 10 times as fast as unmodified LDL. The modified LDL was toxic to macrophages in the absence of serum. 2.
D S, Leake, S M, Rankin
openaire   +2 more sources

Revisited role of B cells in atherosclerosis [PDF]

, 2012
No abstract ...
Blair, Paula, Maffia, Pasquale
core   +1 more source

Immunological and functional properties of in vitro oxidized low density lipoprotein.

Journal of Lipid Research, 1995
We studied the effect of in vitro moderate oxidation on low density lipoprotein (LDL) conformation and metabolism. LDL was modified with either copper ions or phospholipase A2 plus lipoxygenase and, in both cases, mild oxidative conditions were used. The
P Harduin, A Tailleux, S Lestavel, V Clavey, J C Fruchart, C Fievet   +5 more
doaj   +1 more source

Paraoxonase 2 protein is spatially expressed in the human placenta and selectively reduced in labour [PDF]

, 2014
Humans parturition involves interaction of hormonal, neurological, mechanical stretch and inflammatory pathways and the placenta plays a crucial role.
A Abdulsid, A Abdulsid, A Abdulsid, A Many, Akrem Abdulsid, Ana Claudia Zenclussen, C Burdon, CJ Ng, CL Elliott, DA Stoltz, DI Draganov, DI Draganov, F Petraglia, Fiona Lyall, H-H Peng, HS Brar, I Witte, JF Teiber, JM McCord, JRG Challis, Kevin Hanretty, KJ Lee, M Shiner, R Lim, RS Dwarakanath, S Horke, Samy Alwarfaly, SL Primo-Parma, T Cindrova-Davies, U Borell, V Sitras, VC Allport, Y Xu   +32 more
core   +3 more sources

Oxidative Low Density Lipoprotein and Exercise: A Historical and Meta-Analysis [PDF]

, 2012
PURPOSE: The purpose of this study is to use the meta-analytic approach to determine the impact of exercise on oxidized low density lipoproteins in an adolescent population and the role of oxidized low density lipoprotein in the etiology of ...
Kilgore, Lon, Tailor, Nikita, Velasquez, Benito, Wyatt, Frank   +3 more
core   +1 more source

Toxicity of enzymically-oxidized low-density lipoprotein

Biochemical and Biophysical Research Communications, 1987
Intravenous injection of cholesterol oxidase into hyperlipidemic rabbits in which aortic atheromatous lesions have been induced by dietary means is lethal within hours, whereas injection of the same enzyme into normal rabbits has no visible adverse effect.
A W, Bernheimer, W G, Robinson, R, Linder, D, Mullins, Y K, Yip, N S, Cooper, I, Seidman, T, Uwajima   +7 more
openaire   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source