Results 181 to 190 of about 203,353 (285)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization Via Regulating the Wnt/β-catenin/Autophagy Axis. [PDF]

Inflammation
Chen M, Liu Y, Li J, Wang Z, Zhang Y, Chen X, Li X, Xia N, Yu W, Sun L, Xiao Y, Zhu H, Wei J, Pu L, Han S.   +14 more
europepmc   +1 more source

Impact of a short-term low calorie diet alone or with interval exercise on quality of life and oxidized phospholipids in obese females. [PDF]

Physiol Behav, 2022
Gilbertson NM, Eichner NZM, Gaitán JM, Pirtle JM, Kirby JL, Upchurch CM, Leitinger N, Malin SK.   +7 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections. [PDF]

Immunity
Di Gioia M, Poli V, Tan PJ, Spreafico R, Chu A, Cuenca AG, Wu Z, Benamar M, Pandolfi L, Meloni F, Askarian F, Hsiao J, Borroum E, Nizet V, Gordts PLSM, Witztum JL, Chatila TA, Chou J, Zhou X, Springstead JR, Zanoni I.   +20 more
europepmc   +1 more source

Correction to: Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. [PDF]

Circulation, 2022
europepmc   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Oxidized phospholipids during microbial challenge: friend or foe? [PDF]

Genes Immun
Colaço HG, Voss K.
europepmc   +1 more source

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

, 2023
Di Gioia M, Poli V, Tan PJ, Spreafico R, Chu A, Cuenca AG, Gordts PL, Pandolfi L, Meloni F, Witztum JL, Chou J, Springstead JR, Zanoni I.   +12 more
europepmc   +1 more source