Results 241 to 250 of about 203,353 (285)

Oxidized phospholipids in Doxorubicin-induced cardiotoxicity

Chemico-Biological Interactions, 2019
Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids. In cardiomyocytes, Dox increases oxidation of a species of phospholipids, phosphatidylcholine, which has ...
Elissavet Kardami, Navid Koleini
exaly   +3 more sources

Oxidized phospholipids in cardiovascular disease

Nature Reviews Cardiology, 2023
Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma on apolipoprotein B (apoB)-containing lipoproteins. When initially conceptualized, OxPL-apoB measurement in plasma was expected to reflect the concentration of minimally oxidized ...
Sotirios Tsimikas, Joseph L. Witztum
openaire   +2 more sources

Phospholipid oxidation in emulsions

Lipids, 1970
AbstractThe autoxidation of purified phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC), extracted from egg and soybean lipids, was followed by oxygen uptake measurements in emulsified systems. All emulsified phospholipid fractions had comparable activation energies.
G A, Corliss, L R, Dugan
openaire   +2 more sources

Oxidized phospholipids and isoprostanes in atherosclerosis

Current Opinion in Lipidology, 1998
Lipid oxidation has been shown to be a prominent feature of atherosclerosis. The presence of isoprostanes and other lipid oxidation products has been clearly demonstrated in lesions. Furthermore, antibodies to oxidized phospholipids have been identified in animal and human models.
J L, Witztum, J A, Berliner
openaire   +2 more sources

Oxidized phospholipids, isolevuglandins, and atherosclerosis

Molecular Nutrition & Food Research, 2005
Autoxidation of polyunsaturated phosphatidylcholines (PCs) generates isolevuglandins (isoLGs) through rearrangements of isoprostanoid endoperoxides. Within seconds, isoLGs are sequestered by covalent adduction with proteins. Murine plasma isoLG-protein levels increased at least 2.5-fold in response to inflammation.
Wujuan, Zhang, Robert G, Salomon
openaire   +2 more sources

Bioactive phospholipid oxidation products

Free Radical Biology and Medicine, 2000
Oxidation of phospholipids results in chain-shortened fragments and oxygenated derivatives of polyunsaturated sn-2 fatty acyl residues, generating a myriad of phospholipid products. Certain oxidation products of phosphatidylcholine bind to and activate the human receptor for PAF, and these PAF-like lipids are potent, selective inflammatory mediators ...
G K, Marathe, K A, Harrison, R C, Murphy, S M, Prescott, G A, Zimmerman, T M, McIntyre   +5 more
openaire   +2 more sources

Determination of pyrrolized phospholipids in oxidized phospholipid vesicles and lipoproteins

Analytical Biochemistry, 2004
The Ehrlich reaction was optimized to determine pyrrolized phospholipids produced as a consequence of oxidative stress. The procedure consisted of the treatment of the modified phospholipids with p-(dimethylamino)benzaldehyde at a controlled acidity temperature and the spectrophotometric determination of adducts produced.
Francisco J, Hidalgo, Fátima, Nogales, Rosario, Zamora   +2 more
openaire   +2 more sources

Oxidized phospholipids as novel mediators of neurodegeneration

Trends in Neurosciences, 2022
Neurodegeneration drives the progression of many neurological diseases. Inflammation and oxidative stress occurring in the CNS promote lipid peroxidation, leading to the generation of oxidized phospholipids such as oxidized phosphatidylcholines (OxPCs).
Yifei Dong, V. Wee Yong
openaire   +2 more sources

Inflammatory profile of oxidized phospholipids

Thrombosis and Haemostasis, 2007
SummaryLipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells.
openaire   +2 more sources

Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. [PDF]

Journal of the American College of Cardiology, 2014
ObjectivesThis study sought to assess whether oxidized lipids are released downstream from obstructive plaques after percutaneous coronary and peripheral interventions using distal protection devices.BackgroundOxidation of lipoproteins generates multiple
Saad Sultan Ghumman, Gregor Leibundgut
exaly   +2 more sources