Results 91 to 100 of about 90,447 (247)

Selective Oxidation of α,β‐Unsaturated Alcohols With Lyophilisates of Bjerkandera adusta

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The biocatalytic aerobic production of (E)‐2‐allylic aldehydes from their corresponding alcohols using lyophilisates of the basidiomycetous fungus Bjerkandera adusta is reported. The addition of small amounts of organic solvents to the reaction media increased the reaction and substrate conversion rates, allowing for to produce (E)‐aldehydes ...
Letizia Calza   +4 more
wiley   +1 more source

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus Aureus by Coordination to Rhenium Carbonyl Complexes

open access: yesChemBioChem, EarlyView.
Coordination of antifungal azoles to rhenium di‐ and tricarbonyl complexes results in compounds with enhanced antimicrobial efficacy—up to 32‐fold minimum inhibitory concentration improvement—against methicillin‐sensitive and methicillin‐resistant Staphylococcus aureus over parent azoles.
Kevin Schindler   +12 more
wiley   +1 more source

Rational Design of Hydrophilic Deep Eutectic Solvents to Outperform Oxidoreductase Activity in Aqueous Media

open access: yesChemCatChem, EarlyView.
This study investigates the catalytic performance of alcohol dehydrogenases (ADHs) — including thermostability, specific activity, and kinetics — in mixtures of glycerol‐based deep eutectic solvents (DESs) and aqueous buffers. By elucidating enzyme—DES interactions, the work identifies the outperforming hydrophilic DESs that enhance redox biocatalysis,
Ningning Zhang   +6 more
wiley   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

open access: yesChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato   +6 more
wiley   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue   +7 more
wiley   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang   +6 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami   +4 more
wiley   +1 more source

Mycofactocin and the mycobacterial electron transport chain

open access: yeseLife
In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
Stephanie M Stuteley, Ghader Bashiri
doaj   +1 more source

Home - About - Disclaimer - Privacy