Quorum Quenching Revisited—From Signal Decays to Signalling Confusion
Sensors, 2012 In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past
Kok-Gan Chan +4 more
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Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. [PDF]
, 2014 Mitochondrial diseases due to a reduced capacity for oxidative phosphorylation were first identified more than 20 years ago, and their incidence is now recognized to be quite significant.
Scheffler, Immo E
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Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]
, 2006 The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial ...
Abdul +39 more
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eLife, 2022 Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the Bacillus cereus ribonucleotide reductase R2b–NrdI complex, a di-metal ...
Juliane John +26 more
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How are proteins reduced in the endoplasmic reticulum? [PDF]
, 2018 The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil +2 more
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eLife, 2022 Oxidative stress-mediated formation of protein hydroperoxides can induce irreversible fragmentation of the peptide backbone and accumulation of cross-linked protein aggregates, leading to cellular toxicity, dysfunction, and death.
Takeshi Imai +5 more
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Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]
, 2014 BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo +8 more
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Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]
, 2015 OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew +5 more
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Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]
, 2020 Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A. +6 more
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The Spermatophore in Glossina morsitans morsitans: Insights into Male Contributions to Reproduction. [PDF]
, 2016 Male Seminal Fluid Proteins (SFPs) transferred during copulation modulate female reproductive physiology and behavior, impacting sperm storage/use, ovulation, oviposition, and remating receptivity.
Abd-Alla, Adly MM +8 more
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