Results 101 to 110 of about 43,837 (307)
Beitrag zur Charakterisierung des Oxidoreductase-Inhibitors [PDF]
, 1976 H. Gallati
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Chemistry &Biodiversity, EarlyView.ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
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ChemBioChem, EarlyView.This study describes the successful identification of ancestral sequences N50 and N49, which have a longer half‐life of approximately four and two times the wild‐type Sp‐amine transaminase, respectively.. This approach effectively enhances the thermal stability of the transaminase.
Luyao Zhao +4 more
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Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols
ChemBioChem, EarlyView.Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen +4 more
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Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health
British Journal of Pharmacology, EarlyView., 2023 Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue +7 more
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Oxidoreductases: Significance for Humans and Microorganism
, 2021 Oxidoreductases consist of a large class of enzymes catalyzing the transfer of electrons from an electron donor (reductant) to an electron acceptor (oxidant) molecule. Since so many chemical and biochemical transformations comprise oxidation/reduction processes, it has long been an important goal in biotechnology to develop practical biocatalytic ...
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ChemBioChem, Accepted Article.Hydrazine synthetases (HSs), consisting of cupin and methionyl‐tRNA synthetase (MetRS)‐like domains, catalyze hydrazine formation in the biosynthesis of various nitrogen‐nitrogen (N‐N) bond‐containing secondary metabolites. The structural diversity of the N‐N bond‐containing secondary metabolites synthesized using this system is attributed to the ...
Yusuke Shikai +4 more
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NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, EarlyView., 2023 The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
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The role of phospholipids in the reduction of ubiquinone analogues by the mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase complex [PDF]
, 1978 C I Ragan
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ChemBioChem, Accepted Article.In this study, a library of rhenium di‐ and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands was synthesized and characterized. Their antimicrobial activity was evaluated against both methicillin‐sensitive (MSSA) and methicillin‐resistant (MRSA) Staphylococcus aureus, and selected compounds were also assessed for ...
Kevin Schindler +12 more
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