Results 161 to 170 of about 44,293 (292)

Proteomic analysis reveals phage-driven metabolic shifts and biofilm disruption in methicillin-resistant Staphylococcus aureus (MRSA). [PDF]

open access: yesWorld J Microbiol Biotechnol
Dakheel KH   +6 more
europepmc   +1 more source

Comparative Dynamics Enables Discovery of Embedded Bacterial Ferredoxin Domains in Large Redox Enzymes

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Bacterial ferredoxins are small iron–sulfur binding proteins that function as soluble electron shuttles between redox enzymes in the cell. Their simple 2×(β–α–β) fold, central metabolic function, and ubiquity across all kingdoms of life have led to the proposal that ferredoxins were likely among the earliest proteins.
Jan A. Siess, Vikas Nanda
wiley   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink   +5 more
wiley   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras   +5 more
wiley   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

open access: yesSmall, EarlyView.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho   +10 more
wiley   +1 more source

The role of metabolism in shaping enzyme structures over 400 million years. [PDF]

open access: yesNature
Lemke O   +15 more
europepmc   +1 more source

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