Proteomic analysis reveals phage-driven metabolic shifts and biofilm disruption in methicillin-resistant Staphylococcus aureus (MRSA). [PDF]
Dakheel KH+6 more
europepmc +1 more source
ABSTRACT Bacterial ferredoxins are small iron–sulfur binding proteins that function as soluble electron shuttles between redox enzymes in the cell. Their simple 2×(β–α–β) fold, central metabolic function, and ubiquity across all kingdoms of life have led to the proposal that ferredoxins were likely among the earliest proteins.
Jan A. Siess, Vikas Nanda
wiley +1 more source
Obligately Tungsten-Dependent Enzymes─Catalytic Mechanisms, Models and Applications. [PDF]
Szaleniec M, Heider J.
europepmc +1 more source
Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink+5 more
wiley +1 more source
Localization, Purification, and Characterization of Shikimate Oxidoreductase-Dehydroquinate Hydrolyase from Stroma of Spinach Chloroplasts [PDF]
Erich Fiedler, Gernot Schultz
openalex +1 more source
Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras+5 more
wiley +1 more source
NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho+10 more
wiley +1 more source
The role of metabolism in shaping enzyme structures over 400 million years. [PDF]
Lemke O+15 more
europepmc +1 more source
A soluble NADH dehydrogenase (NADH: ferricyanide oxidoreductase) from Thermus aquaticus strain T351 [PDF]
Kenneth A. Walsh+2 more
openalex +1 more source