Results 31 to 40 of about 43,837 (307)

A Review: The Styrene Metabolizing Cascade of Side-Chain Oxygenation as Biotechnological Basis to Gain Various Valuable Compounds

Frontiers in Microbiology, 2018
Styrene is one of the most produced and processed chemicals worldwide and is released into the environment during widespread processing. But, it is also produced from plants and microorganisms.
Michel Oelschlägel, Juliane Zimmerling, Dirk Tischler, Dirk Tischler   +3 more
doaj   +1 more source

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

Frontiers in Chemistry
Oxidoreductases play crucial roles in electron transfer during biological redox reactions. These reactions are not exclusive to protein-based biocatalysts; nano-size (<100 nm), fine-grained inorganic colloids, such as iron oxides and sulfides, also ...
Xiao-Lan Huang, Jeffrey R. Harmer, Gerhard Schenk, Gerhard Schenk, Gerhard Schenk, Gordon Southam, Gordon Southam   +6 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Challenges and perspectives in using unspecific peroxygenases for organic synthesis

Frontiers in Catalysis
In the past 20 years, unspecific peroxygenases (UPOs) have emerged as promising biocatalysts for various organic transformations. Particularly, we have witnessed great attention being paid to the screening of new enzymes and expansion of the substrates ...
Yawen Huang, Yawen Huang, Jiangtao Sha, Jie Zhang, Jie Zhang, Wuyuan Zhang, Wuyuan Zhang, Wuyuan Zhang   +7 more
doaj   +1 more source

The Versatile Applications of DES and Their Influence on Oxidoreductase-Mediated Transformations

Molecules, 2019
In the last decade, new types of solvents called deep eutectic solvents (DES) have been synthesized and commercialized. Among their main advantages, they can be eco-friendly and are easy to synthesize at different molar ratios depending on the desired ...
Fatima Zohra Ibn Majdoub Hassani, Saaid Amzazi, Iván Lavandera   +2 more
doaj   +1 more source

Monothiol and dithiol glutaredoxin-1 from Clostridium oremlandii: identification of domain-swapped structures by NMR, X-ray crystallography and HDX mass spectrometry

IUCrJ, 2020
Protein dimerization or oligomerization resulting from swapping part of the protein between neighboring polypeptide chains is known to play a key role in the regulation of protein function and in the formation of protein aggregates.
Kitaik Lee, Kwon Joo Yeo, Sae Hae Choi, Eun Hye Lee, Bo Keun Kim, Sulhee Kim, Hae-Kap Cheong, Won-Kyu Lee, Hwa-Young Kim, Eunha Hwang, Ju Rang Woo, Sung-Joon Lee, Kwang Yeon Hwang   +12 more
doaj   +1 more source

The ascent of man(made oxidoreductases)

Current Opinion in Structural Biology, 2018
Though established 40 years ago, the field of de novo protein design has recently come of age, with new designs exhibiting an unprecedented level of sophistication in structure and function. With respect to catalysis, de novo enzymes promise to revolutionise the industrial production of useful chemicals and materials, while providing new biomolecules ...
Grayson, Katie, Anderson, Ross
openaire   +5 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Biocatalytic Screening of the Oxidative Potential of Fungi Cultivated on Plant-Based Resources

AppliedChem
The environmental impacts of the postindustrial era, which rely on fossil fuels, have compelled a reconsideration of the future of energy and chemical industries.
Alina Kinner, Stephan Lütz, Katrin Rosenthal   +2 more
doaj   +1 more source